{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:06:23Z","timestamp":1790665583104,"version":"4.1.0"},"reference-count":116,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T00:00:00Z","timestamp":1507507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE019108"],"award-info":[{"award-number":["DE019108"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE021921"],"award-info":[{"award-number":["DE021921"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Dendritic cells (\n                    <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>\n                    s) are antigen\u2010presenting cells that capture, process, and present antigens to lymphocytes to initiate and regulate the adaptive immune response.\n                    <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>\n                    s detect bacteria in skin and mucosa and migrate into regional lymph nodes, where they stimulate antigen\u2010specific T and B lymphocyte activation and proliferation.\n                    <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>\n                    s direct\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4 T cells to differentiate to T\u2010cell subsets such as T helper cells types 1, 2, and 17, and regulatory T cells. The periodontium is chronically exposed to oral bacteria that stimulate an inflammatory response to induce gingivitis or periodontitis.\n                    <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>\n                    s play both protective and destructive roles through activation of the acquired immune response and are also reported to be a source of osteoclast precursors that promote bone resorption.\n                    <jats:styled-content style=\"fixed-case\">FOXO<\/jats:styled-content>\n                    1, a member of the forkhead box O family of transcription factors, plays a significant role in the activation of\n                    <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>\n                    s. The function of\n                    <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>\n                    s in periodontal inflammation has been investigated in a mouse model by lineage\u2010specific deletion of\n                    <jats:styled-content style=\"fixed-case\">FOXO<\/jats:styled-content>\n                    1 in these cells. Deletion of\n                    <jats:styled-content style=\"fixed-case\">FOXO<\/jats:styled-content>\n                    1 reduces\n                    <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>\n                    protective function and enhances susceptibility to periodontitis. The kinase Akt, phosphorylates\n                    <jats:styled-content style=\"fixed-case\">FOXO<\/jats:styled-content>\n                    1 to inhibit\n                    <jats:styled-content style=\"fixed-case\">FOXO<\/jats:styled-content>\n                    activity. Hence the Akt\u2013\n                    <jats:styled-content style=\"fixed-case\">FOXO<\/jats:styled-content>\n                    1 axis may play a key role in regulating\n                    <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>\n                    s to have a significant impact on periodontal disease.\n                  <\/jats:p>","DOI":"10.1111\/omi.12195","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T04:26:49Z","timestamp":1503894409000},"page":"13-21","source":"Crossref","is-referenced-by-count":124,"title":["The function of dendritic cells in modulating the host response"],"prefix":"10.1111","volume":"33","author":[{"given":"L.","family":"Song","sequence":"first","affiliation":[{"name":"Department of Periodontics School of Dental Medicine University of Pennsylvania  Philadelphia PA USA"},{"name":"Department of Stomatology The Fifth People's Hospital of Shanghai Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Periodontics School of Dental Medicine University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Periodontics School of Dental Medicine University of Pennsylvania  Philadelphia PA USA"},{"name":"Molecular Laboratory for Gene Therapy and Tooth Regeneration and Department of Orthodontics Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4664-8529","authenticated-orcid":false,"given":"D.T.","family":"Graves","sequence":"additional","affiliation":[{"name":"Department of Periodontics School of Dental Medicine University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0709-679"},{"key":"e_1_2_7_3_1","first-page":"513","article-title":"Pattern of distribution of T lymphocytes, Langerhans cells and HLA\u2010DR bearing cells in normal human oral mucosa","volume":"93","author":"Reibel J","year":"1985","journal-title":"Scand J Dent Res"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/32588"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.12.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515625962"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1116770109"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90175-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/690643"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.2.283"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086657"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324392"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324549"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.1499"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-017-8931-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.1.17-27.2005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020437"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3865"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1141"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040602"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0912452"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00885.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.11.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.01.002"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.66.2.205"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-11-0097"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1822"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01611.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040317"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.4.1666"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00237.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.028"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2016.16.1.1"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3123"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00389-8"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00208-5"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-468017"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2015.110"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300328"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329675"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091636"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.03.013"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511407338"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790080401"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939722"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.6.3453-3461.2005"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12345"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080287"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12415"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600409"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2008.00463.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110482"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/35046102"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510376402"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01209-07"},{"key":"e_1_2_7_57_1","first-page":"2482","article-title":"Differential roles of Porphyromonas gingivalis lipopolysaccharide and Escherichia coli lipopolysaccharide in maturation and antigen\u2010presenting functions of dentritic cells","volume":"19","author":"Su H","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_7_58_1","first-page":"223","article-title":"The effects of Porphyromonas gingivalis LPS and Actinobacillus actinomycetemcomitans LPS on human dendritic cells in vitro, and in a mouse model in vivo","volume":"24","author":"Mahanonda R","year":"2006","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.05.010"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023381027062"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.08.018"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.4.1895"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOCI.0000029116.12371.bf"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1994.tb00072.x"},{"key":"e_1_2_7_65_1","first-page":"45","article-title":"Comparative evaluation of IFN\u03b3, IL4 and IL17 cytokines in healthy gingiva and moderate to advanced chronic periodontitis","volume":"7","author":"Behfarnia P","year":"2010","journal-title":"Dent Res J (Isfahan)"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01712.x"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100683"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00044.x"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.3.1313"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01390.x"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03318.x"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01586.x"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.045"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00760.x"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.148644"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39514"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507326200"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.10.4682-4685.1994"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004647"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203266"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3024"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.216523"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2012.01945.x"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4693"},{"key":"e_1_2_7_85_1","first-page":"173","article-title":"Immunohistochemical analysis of Langerhans cells in chronic gingivitis using anti\u2010CD1a antibody","volume":"11","author":"Jaitley S","year":"2014","journal-title":"Dent Res J (Isfahan)"},{"key":"e_1_2_7_86_1","first-page":"163","article-title":"Langerhans cell dynamics in human gingiva during experimentally induced inflammation","volume":"20","author":"Moughal NA","year":"1992","journal-title":"J Biol Buccale"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00764.x"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.04.022"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.2.389"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070314"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0041"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636534"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-132787"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090829"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133917"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/939751"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515586353"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.12.8711"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11581"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401754"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.258053"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078541"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12459"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.03.010"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.017"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22348"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-028951"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2003.12.004"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002753"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804093"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.098459"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070763"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.268"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42834"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12131"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115635109"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501281"}],"container-title":["Molecular Oral Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fomi.12195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/omi.12195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T14:07:02Z","timestamp":1695910022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/omi.12195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,9]]},"references-count":116,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/omi.12195"],"URL":"https:\/\/doi.org\/10.1111\/omi.12195","archive":["Portico"],"relation":{},"ISSN":["2041-1006","2041-1014"],"issn-type":[{"value":"2041-1006","type":"print"},{"value":"2041-1014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,9]]}}}