{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:08:52Z","timestamp":1790791732631,"version":"4.1.0"},"reference-count":106,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Volatile sulfur compounds (VSCs) such as hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) and methyl mercaptan (CH\n                    <jats:sub>3<\/jats:sub>\n                    SH) are the main components of oral malodor, and are produced as the end products of the proteolytic processes of oral microorganisms. The main pathway of proteolysis is the metabolism of sulfur\u2010containing amino acids by gram\u2010negative anaerobic bacteria. Gram\u2010positive bacteria may promote VSC production by gram\u2010negative anaerobes by cleaving sugar chains from glycoproteins and thus providing proteins. A large variety of bacteria within the oral microbiota are thought to be involved in the complex phenomenon of halitosis. Oral microbiota associated with a lack of oral malodor, oral microbiota associated with severe and H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010dominant oral malodor, and oral microbiota associated with severe and CH\n                    <jats:sub>3<\/jats:sub>\n                    SH\u2010dominant oral malodor have been distinguished through molecular approaches using the 16S rRNA gene. Pathological halitosis may primarily be addressed through treatment of causative diseases. In all cases, plaque control is the basis of oral malodor control, and dentifrices, mouthwashes, and functional foods play a supplementary role in addition to brushing. Recently, the use of natural ingredients in products tends to be favored due to the increase in antibiotic\u2010resistant strains and the side effects of some chemical ingredients. In addition, probiotics and vaccines are expected to offer new strategies for improving the oral conditions through mechanisms other than antibacterial agents.\n                  <\/jats:p>","DOI":"10.1111\/omi.12259","type":"journal-article","created":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T10:54:44Z","timestamp":1553943284000},"page":"85-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Induction and inhibition of oral malodor"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2569-2846","authenticated-orcid":false,"given":"Nao","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Preventive and Public Health Dentistry Fukuoka Dental College Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of General Dentistry Fukuoka Dental College Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Faculty of Dental Science Kyushu University Fukuoka Japan"},{"name":"OBT Research Center, Faculty of Dental Science Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Hirofuji","sequence":"additional","affiliation":[{"name":"Department of General Dentistry Fukuoka Dental College Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hanioka","sequence":"additional","affiliation":[{"name":"Department of Preventive and Public Health Dentistry Fukuoka Dental College Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00600.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12056"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01575.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(08)70004-9"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.1.37"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-140-12-3407"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00452.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/2\/1\/017017"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-016-0116-y"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12183"},{"key":"e_1_2_4_12_1","first-page":"61106","article-title":"Safety and effectiveness of consumer antiseptics; topical antimicrobial drug products for over\u2010the\u2010counter human use. Final Rule","volume":"81","author":"Food and Drug Administration, HHS","year":"2016","journal-title":"Federal Register"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.03.139"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345940730060701"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(60)90473-X"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050141"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2007.0325"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.11.027"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01640.x"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.05.021"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.03.032"},{"key":"e_1_2_4_22_1","first-page":"CD008676","article-title":"Chlorhexidine mouthrinse as an adjunctive treatment for gingival health","volume":"3","author":"James P.","year":"2017","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-35"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.02.022"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.2.558-563.2003"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2011.640281"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2014.887770"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.9.768"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00162-8"},{"key":"e_1_2_4_30_1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/clinchem\/27.6.842","article-title":"Quantitative differences in volatiles from healthy mouths and mouths with periodontitis","volume":"27","author":"Kostelc J. G.","year":"1981","journal-title":"Clinical Chemistry"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.6.577"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00308.x"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/NNR.0b013e3182a53b3a"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/18803"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.02.047"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00266.2011"},{"issue":"28","key":"e_1_2_4_37_1","first-page":"256","article-title":"Microbiology and treatment of halitosis","volume":"2002","author":"Loesche W. J.","year":"2000","journal-title":"Periodontology"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.7.630"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.07.015"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-14-4"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01392.x"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12132"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0557-z"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028009813.x"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-595X.2002.tb00921.x"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-016-0199-7"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01586-1"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173686"},{"key":"e_1_2_4_49_1","first-page":"330","article-title":"Anaphylactoid shock caused by chlorhexidine gluconate","volume":"47","author":"Nikaido S.","year":"1998","journal-title":"Masui. the Japanese Journal of Anesthesiology"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/6\/1\/017107"},{"key":"e_1_2_4_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0902-0055.2003.00112.x"},{"key":"e_1_2_4_52_1","doi-asserted-by":"publisher","DOI":"10.4103\/2279-042X.179568"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1990.tb00645.x"},{"key":"e_1_2_4_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01395.x"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345810600111101"},{"key":"e_1_2_4_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00507.x"},{"key":"e_1_2_4_57_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.5.705"},{"key":"e_1_2_4_58_1","first-page":"975148","article-title":"Effect of green tea mouthwash on oral malodor","volume":"2013","author":"Rassameemasmaung S.","year":"2012","journal-title":"ISRN Preventive Medicine"},{"key":"e_1_2_4_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24481"},{"key":"e_1_2_4_60_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1605.05012"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2007.01371.x"},{"key":"e_1_2_4_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00621.x"},{"key":"e_1_2_4_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-003-0214-7"},{"key":"e_1_2_4_64_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.60.745"},{"key":"e_1_2_4_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600240"},{"key":"e_1_2_4_66_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6923.217"},{"key":"e_1_2_4_67_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7163\/aa7c24"},{"key":"e_1_2_4_68_1","first-page":"79","article-title":"Clinical effectiveness of a dentifrice containing triclosan and a copolymer for controlling breath odor","volume":"20","author":"Sharma N. C.","year":"2007","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_4_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1543-1552.2005"},{"key":"e_1_2_4_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01306.x"},{"key":"e_1_2_4_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-9-71"},{"key":"e_1_2_4_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-11-14"},{"key":"e_1_2_4_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12378"},{"key":"e_1_2_4_74_1","first-page":"182","article-title":"\u03b2\u2010galactosidase activity in saliva is associated with oral malodor","volume":"81","author":"Sterer N.","year":"2002","journal-title":"Journal of Dental Research"},{"key":"e_1_2_4_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-595X.2002.tb00930.x"},{"key":"e_1_2_4_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608501007"},{"key":"e_1_2_4_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-016-0255-3"},{"key":"e_1_2_4_78_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2017-0161"},{"key":"e_1_2_4_79_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/6\/1\/017106"},{"key":"e_1_2_4_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.12.400"},{"key":"e_1_2_4_81_1","first-page":"25","article-title":"Relationship between oral malodor and glycosylated salivary proteins","volume":"57","author":"Takehara S.","year":"2010","journal-title":"Journal of Medical and Dental Sciences"},{"key":"e_1_2_4_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02304-09"},{"key":"e_1_2_4_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep00215"},{"key":"e_1_2_4_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.12.1854"},{"key":"e_1_2_4_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.09.011"},{"key":"e_1_2_4_86_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100249"},{"key":"e_1_2_4_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2004.05.021"},{"key":"e_1_2_4_88_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/4\/1\/017003"},{"key":"e_1_2_4_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12155"},{"key":"e_1_2_4_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(71)90062-8"},{"key":"e_1_2_4_91_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1977.48.1.13"},{"key":"e_1_2_4_92_1","first-page":"309","article-title":"Oral malodour: An indicator of health status and oral cleanliness","volume":"28","author":"Tonzetich J.","year":"1978","journal-title":"International Dental Journal"},{"key":"e_1_2_4_93_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350802516170"},{"key":"e_1_2_4_94_1","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1128\/iai.63.9.3401-3410.1995","article-title":"Cytopathic effects of Treponema denticola chemotrypsin\u2010like proteinase on migrating and stratified epithelial cells","volume":"63","author":"Uitto V. J.","year":"1995","journal-title":"Infection and Immunity"},{"key":"e_1_2_4_95_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2012.734404"},{"key":"e_1_2_4_96_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46118-0"},{"key":"e_1_2_4_97_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.011"},{"key":"e_1_2_4_98_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/6\/1\/017101"},{"key":"e_1_2_4_99_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.9.783"},{"key":"e_1_2_4_100_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513507065"},{"key":"e_1_2_4_101_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.59.1232"},{"key":"e_1_2_4_102_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/4\/1\/017108"},{"key":"e_1_2_4_103_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-148-12-3961"},{"key":"e_1_2_4_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02803-6"},{"key":"e_1_2_4_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02958-7"},{"key":"e_1_2_4_106_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.6912-6916.2000"},{"key":"e_1_2_4_107_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2003.00063.x"}],"container-title":["Molecular Oral Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/omi.12259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/omi.12259","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/omi.12259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T08:12:10Z","timestamp":1694247130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/omi.12259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,22]]},"references-count":106,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/omi.12259"],"URL":"https:\/\/doi.org\/10.1111\/omi.12259","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/OMI.12259\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12259\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12259\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12259\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12259\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12259\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12259\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.14322\/publons.r5285425","asserted-by":"object"}]},"ISSN":["2041-1006","2041-1014"],"issn-type":[{"value":"2041-1006","type":"print"},{"value":"2041-1014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,22]]},"assertion":[{"value":"2019-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}