{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:24:57Z","timestamp":1783571097952,"version":"3.55.0"},"reference-count":81,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p><jats:italic>Porphyromonas gingivalis<\/jats:italic> has been strongly associated with chronic periodontitis, which affects tooth\u2010supporting tissues. This Gram\u2010negative anaerobic bacterium produces a repertoire of virulence factors that modulate tissue destruction directly or indirectly by the induction of inflammatory processes. The aim of this study was to investigate the effects of resveratrol, a major polyphenol found in grapes and wine, on the growth and virulence properties of <jats:italic>P.\u00a0gingivalis<\/jats:italic> as well as on gingival keratinocyte tight junction integrity and the host inflammatory response. Resveratrol exhibited antibacterial activity that may result from damage to the bacterial cell membrane. Resveratrol also killed a pre\u2010formed <jats:italic>P.\u00a0gingivalis<\/jats:italic> biofilm and reduced bacterial adherence to matrix proteins. In addition, resveratrol had a protective effect on the integrity of the keratinocyte tight junctions by inhibiting its breakdown by <jats:italic>P.\u00a0gingivalis<\/jats:italic>. This may be related to the ability of resveratrol to inhibit the protease activities of <jats:italic>P.\u00a0gingivalis<\/jats:italic>. Lastly, resveratrol reduced <jats:italic>P.\u00a0gingivalis<\/jats:italic>\u2010mediated activation of the NF\u2010\u03baB signaling pathway and attenuated TREM\u20101 gene expression as well as soluble TREM\u20101 secretion in monocytes. The effect on NF\u2010\u03baB activation likely results from the ability of resveratrol to act as a PPAR\u2010\u03b3 agonist. In summary, the antibacterial, anti\u2010adherence, and antiprotease properties of resveratrol, as well as its ability to protect the gingival keratinocyte barrier and attenuate the inflammatory response in monocytes suggest that it may be a promising novel therapeutic agent for treating periodontal disease.<\/jats:p>","DOI":"10.1111\/omi.12260","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T23:43:08Z","timestamp":1554507788000},"page":"118-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Resveratrol attenuates the pathogenic and inflammatory properties of <i>Porphyromonas gingivalis<\/i>"],"prefix":"10.1111","volume":"34","author":[{"given":"Amel","family":"Ben Lagha","sequence":"first","affiliation":[{"name":"Oral Ecology Research Group, Faculty of Dentistry Universit\u00e9 Laval Quebec City QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisoa","family":"Andrian","sequence":"additional","affiliation":[{"name":"Oral Ecology Research Group, Faculty of Dentistry Universit\u00e9 Laval Quebec City QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0878-4674","authenticated-orcid":false,"given":"Daniel","family":"Grenier","sequence":"additional","affiliation":[{"name":"Oral Ecology Research Group, Faculty of Dentistry Universit\u00e9 Laval Quebec City QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.1.90"},{"key":"e_1_2_7_3_1","first-page":"126","article-title":"Molecular structure of tight junctions and their role in epithelial transport","volume":"16","author":"Anderson J. 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