{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:28:14Z","timestamp":1790112494081,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The use of next generation sequencing and bioinformatics has revealed the complexity and richness of the human oral microbiota. While some species are well known for their periodontal pathogenicity, the molecular\u2010based approaches for bacterial identification have raised awareness about new putative periodontal pathogens. Although they are found increased in case of periodontitis, there is currently a lack of data on their interrelationship with the periodontal measures. We processed the sequencing data of the subgingival microbiota of 75 patients with hemochromatosis and chronic periodontitis in order to characterize the well\u2010described and newly identified subgingival periodontal pathogens. We used correlation tests and statistical models to assess the association between the periodontal pathogens and mean pocket depth, and to determine the most relevant bacterial biomarkers of periodontitis severity. Based on correlation test results, nine taxa were selected and included in the statistical models. The multiple linear regression models adjusted for systemic and periodontal clinical variables showed that mean pocket depth was negatively associated with\n                    <jats:italic>Aggregatibacter<\/jats:italic>\n                    and\n                    <jats:italic>Rothia<\/jats:italic>\n                    , and positively associated with\n                    <jats:italic>Porphyromonas<\/jats:italic>\n                    . Furthermore, a bacterial ratio that was previously described as a signature of dysbiosis in periodontitis (%\n                    <jats:italic>Porphyromonas<\/jats:italic>\n                    +%\n                    <jats:italic>Treponema<\/jats:italic>\n                    +%\n                    <jats:italic>Tannerella<\/jats:italic>\n                    )\/(%\n                    <jats:italic>Rothia<\/jats:italic>\n                    +%\n                    <jats:italic>Corynebacterium<\/jats:italic>\n                    ) was the most significant predictor. In this specific population, we found that the best model in predicting the mean pocket depth was microbial dysbiosis using the dysbiosis ratio taxa formula. While further studies are needed to assess the validity of these results on the general population, such a dysbiosis ratio could be used in the future to monitor the subgingival microbiota.\n                  <\/jats:p>","DOI":"10.1111\/omi.12274","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T10:05:40Z","timestamp":1575021940000},"page":"19-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Periodontal pathogens and clinical parameters in chronic periodontitis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0208-2084","authenticated-orcid":false,"given":"Emile","family":"Boyer","sequence":"first","affiliation":[{"name":"INSERM INRAE Univ Rennes 1 CHU de Rennes Nutrition Metabolisms and Cancer Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Martin","sequence":"additional","affiliation":[{"name":"INSERM INRAE Univ Rennes 1 CHU de Rennes Nutrition Metabolisms and Cancer Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Le Gall\u2010David","sequence":"additional","affiliation":[{"name":"INSERM INRAE Univ Rennes 1 CHU de Rennes Nutrition Metabolisms and Cancer Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao B.","family":"Fong","sequence":"additional","affiliation":[{"name":"INSERM INRAE Univ Rennes 1 CHU de Rennes Nutrition Metabolisms and Cancer Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Deugnier","sequence":"additional","affiliation":[{"name":"CIC 1414 Inserm Rennes 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