{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:17:33Z","timestamp":1780571853308,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["MD007593"],"award-info":[{"award-number":["MD007593"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic periodontitis is one of the most common infectious inflammatory diseases worldwide. Current therapeutic options for the disease are only partially and temporarily successful due to periodontal re\u2010emergence of pathogens such as\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    , a keystone bacterium in the oral microbial communities, which elicits a dysbiosis between the microbiota and the host. Previously, we reported a peptide inhibitor of\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    (SAPP) that specifically targets\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    and reduces its virulence potential in vitro. Here, we show that SAPP can modulate the ability of\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    to suppress the host innate immune system. Using a cytokine array analysis, we found that the levels of several cytokines including IL\u20106, IL\u20108, and MCP\u20101 in the culture media of human oral keratinocytes (HOKs) were significantly diminished in the presence of\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    . Whereas the levels of these cytokines were restored, at least partially, in the culture media of HOKs by SAPP treatment. Furthermore, we also observed in an ex vivo assay that SAPP efficiently inhibited biofilm primed formation by mixed\u2010species oral bacteria, and significantly dampened the abnormally innate immune responses induced by these bacteria. We also demonstrated, using a mouse model, that SAPP could prevent alveolar bone loss induced by\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    . Our results suggest that SAPP specifically targets\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    and its associated bacterial communities and could be envisioned as an emerging therapy for periodontitis.\n                  <\/jats:p>","DOI":"10.1111\/omi.12305","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T20:49:59Z","timestamp":1593550199000},"page":"193-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["In vivo and ex vivo actions of a novel\n                    <i>P. gingivalis<\/i>\n                    inhibitor on multi\u2010species biofilm, inflammatory response, and periodontal bone loss"],"prefix":"10.1111","volume":"35","author":[{"given":"Meng\u2010Hsuan","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Oral Biology Meharry Medical College Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Hasturk","sequence":"additional","affiliation":[{"name":"Department of Applied Oral Sciences Center for Clinical and Translational Research The Forsyth Institute Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne F.","family":"Young","sequence":"additional","affiliation":[{"name":"General Practice Residency Program Meharry Medical College Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1712-3256","authenticated-orcid":false,"given":"Hua","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Meharry Medical College Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290111.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau3333"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006932"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00020.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3785"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2873"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.10.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12246"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01551-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16522-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514537828"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2013.09.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.11.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.62.4.1244-1263.1998"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1995.tb01249.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.1340010"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1977.tb00112.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01409.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12732"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01730.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12317"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00072-09"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00284-10"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.24.7067-7069.2000"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01469.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/009050-0"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2014.999567"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01136-13"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.1998.0277"}],"container-title":["Molecular 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