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Biofilm formation of bacteria is important for the initiation and progression of such diseases. Although lipoproteins play key roles in physiological functions, the role of lipoproteins of\n                    <jats:italic>S. gordonii<\/jats:italic>\n                    in its biofilm formation has not been clearly understood. In this study, we investigated the role of lipoproteins of\n                    <jats:italic>S. gordonii<\/jats:italic>\n                    in the bacterial biofilm formation using its lipoprotein\u2010deficient strain (\n                    <jats:italic>\u0394lgt<\/jats:italic>\n                    ). The\n                    <jats:italic>S. gordonii \u0394lgt<\/jats:italic>\n                    exhibited increased biofilm formation on the human dentin slices or on the polystyrene surfaces compared to the wild\u2010type strain, while its growth rate did not differ from that of the wild\u2010type. In addition, the\n                    <jats:italic>S. gordonii \u0394lgt<\/jats:italic>\n                    strain exhibited the enhanced LuxS mRNA expression and AI\u20102 production, which is known to be a positive regulator of biofilm formation, compared to the wild\u2010type. Concordantly, the augmented biofilm formation of\n                    <jats:italic>S. gordonii \u0394lgt<\/jats:italic>\n                    was attenuated by an AI\u20102 inhibitor, D\u2010ribose. In addition, lipoproteins from purified\n                    <jats:italic>S. gordonii<\/jats:italic>\n                    inhibited the biofilm formation of\n                    <jats:italic>S. gordonii<\/jats:italic>\n                    wild\u2010type and\n                    <jats:italic>\u0394lgt<\/jats:italic>\n                    . Taken together, these results suggest that lipoprotein\u2010deficient\n                    <jats:italic>S. gordonii<\/jats:italic>\n                    form biofilms more effectively than the wild\u2010type strain, which might be related to the AI\u20102 quorum\u2010sensing system.\n                  <\/jats:p>","DOI":"10.1111\/omi.12319","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T01:46:32Z","timestamp":1602812792000},"page":"271-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Enhanced biofilm formation of\n                    <i>Streptococcus gordonii<\/i>\n                    with lipoprotein deficiency"],"prefix":"10.1111","volume":"35","author":[{"given":"Ok\u2010Jin","family":"Park","sequence":"first","affiliation":[{"name":"Department of Oral Microbiology and Immunology DRI, and BK21 Plus Program School of Dentistry Seoul National University  Seoul Republic of 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