{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:32:27Z","timestamp":1783092747111,"version":"3.54.6"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    COVID\u201019, caused by the SARS\u2010CoV\u20102 virus, has become a significant global public health problem, with a wide variety of clinical manifestations and disease progression outcomes. LncRNAs are key regulators of the immune response and have been associated with COVID\u201019 risk infection. Previous studies focused mainly on in\u2010silico analysis of lncRNA expression in the lungs or peripheral blood cells. We evaluated the expression of lncRNAs NEAT1, MALAT1, and MIR3142 in saliva and nasopharyngeal swab from SARS\u2010CoV\u20102 positive (n\u00a0=\u00a034) and negative patients (n\u00a0=\u00a046). A higher expression of the lncRNAs NEAT1 and MALAT1 (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.05) were found in positive samples. NEAT1 had a higher expression mainly in saliva samples (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), and MALAT1 was upregulated in nasopharyngeal samples (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). Area under the ROC curve for NEAT1 in saliva was 0.8067. This study was the first to investigate the expression of lncRNAs in saliva and nasopharyngeal samples of COVID\u201019 patients, which gives new insights into the initial response to infection and infectivity and may provide new biomarkers for severity and targets for therapy.\n                  <\/jats:p>","DOI":"10.1111\/omi.12351","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T03:19:45Z","timestamp":1630379985000},"page":"291-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["NEAT1 and MALAT1 are highly expressed in saliva and nasopharyngeal swab samples of COVID\u201019 patients"],"prefix":"10.1111","volume":"36","author":[{"given":"Ana Carolina","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"},{"name":"Programa de Pos\u2010gradua\u00e7\u00e3o em Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-2586","authenticated-orcid":false,"given":"Douglas","family":"Adamoski","sequence":"additional","affiliation":[{"name":"Brazilian Biosciences National Laboratory (LNBio) Brazilian Center for Research in Energy and Materials (CNPEM)  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Genelhould","sequence":"additional","affiliation":[{"name":"Programa de Pos\u2010gradua\u00e7\u00e3o em Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"},{"name":"Laborat\u00f3rio de Virologia Complexo Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Zhen","sequence":"additional","affiliation":[{"name":"Unidade de Infectologia Complexo Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Eiji","family":"Yamaguto","sequence":"additional","affiliation":[{"name":"Unidade de Infectologia Complexo Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Savio","family":"Araujo\u2010Souza","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"},{"name":"Programa de Pos\u2010gradua\u00e7\u00e3o em Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6221-2891","authenticated-orcid":false,"given":"Meri Bordignon","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Virologia Complexo Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Mara","family":"Raboni","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Virologia Complexo Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"},{"name":"Unidade de Infectologia Complexo Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia","family":"Bonatto","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"},{"name":"Programa de Pos\u2010gradua\u00e7\u00e3o em Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Fiori","family":"Gradia","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"},{"name":"Programa de Pos\u2010gradua\u00e7\u00e3o em Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-3107","authenticated-orcid":false,"given":"Jaqueline","family":"Carvalho de Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 Brazil"},{"name":"Programa de Pos\u2010gradua\u00e7\u00e3o em Gen\u00e9tica Universidade Federal do Paran\u00e1  Curitiba Paran\u00e1 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