{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:28Z","timestamp":1772160868752,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    colonizes the oral cavity and causes oral candidiasis and early childhood caries synergistically with cariogenic\n                    <jats:italic>Streptococcus mutans<\/jats:italic>\n                    . Colonization of oral tissues with\n                    <jats:italic>C. albicans<\/jats:italic>\n                    is an essential step in the initiation of these infectious diseases. Deleted in malignant brain tumors 1 (DMBT1), also known as salivary agglutinin or gp\u2010340, belongs to the scavenger receptor cysteine\u2010rich (SRCR) superfamily and has important functions in innate immunity. In the oral cavity, DMBT1 causes microbial adherence to tooth enamel and oral mucosa surfaces, but the adherence of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    to DMBT1 has not been examined. In this study, we investigated the binding of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    to DMBT1 and isolated the fungal components responsible for the binding.\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    specifically bound to DMBT1 and strongly bound to the peptide domain SRCRP2. Binding to SRCRP2 was inhibited by\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylneuraminic acid and mannose and by lectins recognizing these sugars. The isolated component had a molecular mass of 25\u00a0kDa, contained sialic acid and mannose residues, and inhibited\n                    <jats:italic>C. albicans<\/jats:italic>\n                    binding to SRCRP2. The localization of the 25\u2010kDa protein on the surface of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    cell walls was confirmed by immunostaining and a cell ELISA using an antiserum to the protein, and Western blotting revealed the presence of the 25\u2010kDa protein in the cell wall fraction of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    . These results suggest that the isolated adhesin is localized on the surface of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    cell walls and that sialic acid and mannose residues in the adhesin play a significant role in the binding reaction.\n                  <\/jats:p>","DOI":"10.1111\/omi.12374","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T20:38:59Z","timestamp":1654720739000},"page":"154-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A novel mannose\u2010containing sialoprotein adhesin involved in the binding of\n                    <i>Candida albicans<\/i>\n                    cells to DMBT1"],"prefix":"10.1111","volume":"37","author":[{"given":"Daisuke","family":"Setoguchi","sequence":"first","affiliation":[{"name":"Department of Preventive Dentistry Kagoshima University Graduate School of Medical and Dental Sciences  Kagoshima 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