{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:16:33Z","timestamp":1787796993030,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771105"],"award-info":[{"award-number":["81771105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objectives<\/jats:bold>\n                    : The objective of this study was to explore the effect of periodontitis on Th\u2010cell subsets in local and systemic environments.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : A total of 32 male Sprague\u2012Dawley rats were randomly divided into periodontitis and control groups. Silk ligatures were applied to the mandibular first (M1) molars in the periodontitis group. Inflammation and alveolar bone loss around the M1 molars were analyzed by histological staining and microcomputed tomography. The mRNA expression of interferon\u2010\u03b3 (IFN\u2010\u03b3), interleukin 4 (IL\u20104), IL\u201017, and IL\u201010 in the gingiva was measured by qRT\u2010PCR. The proportions of Th1, Th2, Th17, and Treg cells in the submandibular lymph nodes, peripheral blood, and jaw bone marrow were tested using flow cytometry.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : More inflammatory cells and alveolar bone resorption were found in the periodontitis group, with upregulated mRNA expression of IFN\u2010\u03b3, IL\u201017, and IL\u201010. The proportion of Th1 and Th17 cells was significantly elevated in submandibular lymph nodes, and the proportion of Th1, Th2, and Th17 cells was significantly elevated in peripheral blood, while the proportion of Th1, Th17, and Treg cells was significantly elevated in jaw bone marrow in the periodontitis group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : This study suggests that periodontitis affects the differentiation of Th\u2010cell subsets in both local and systemic environments, resulting in an increased proportion of proinflammatory cells.\n                  <\/jats:p>","DOI":"10.1111\/omi.12376","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T19:53:32Z","timestamp":1658433212000},"page":"83-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Analysis of Th\u2010cell subsets in local and systemic environments from experimental periodontitis rats"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5936-7008","authenticated-orcid":false,"given":"Yun","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Center for Stomatology Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Center for Stomatology Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhua","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runping","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Center for Stomatology Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.4.494"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.2011.01464.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.6.1009"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.192"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20101759(00)00249\u20100"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2016.1138967"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13205"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510376402"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2010.01586.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.01.010"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00173.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513487559"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.4VMA0315\u2010125RR"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u2010302X.2005.00241.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060180"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102249.1998.00657.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2019.04.009"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080422"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615065114"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2012.715191"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201020\u20107362"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515591790"},{"issue":"3","key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.24425\/pjvs.2021.138727","article-title":"Induction of periodontal disease via retentive ligature, lipopolysaccharide injection, and their combination in a rat model","volume":"24","author":"Mustafa H.","year":"2021","journal-title":"Polish Journal of Veterinary Sciences"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100683"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10928"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.12.020"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1532\u20103382(12)70006\u20104"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027350226435"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/327417"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022526"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.10.014"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010021\u201003856\u20101"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100320(19990401)35:4<318::AID\u2010CYTO4>3.0.CO;2\u20104"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.05.003"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678\u2010775720140259"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12170"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.09.009"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.07.021"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0326"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1607\u2010551X(09)70367\u20105"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.01.007"},{"key":"e_1_2_11_43_1","first-page":"125","article-title":"Study on the immune status of T helper 17 cells in mice with periodontitis","volume":"33","author":"Wang L.","year":"2015","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal of Stomatology"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.1997.tb01391.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.9.5650\u20105660.2001"}],"container-title":["Molecular Oral Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/omi.12376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/omi.12376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/omi.12376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T12:40:54Z","timestamp":1727613654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/omi.12376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,3]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/omi.12376"],"URL":"https:\/\/doi.org\/10.1111\/omi.12376","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/OMI.12376\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12376\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12376\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12376\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12376\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12376\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12376\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12376\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12376\/v3\/review1","asserted-by":"object"}]},"ISSN":["2041-1006","2041-1014"],"issn-type":[{"value":"2041-1006","type":"print"},{"value":"2041-1014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,3]]},"assertion":[{"value":"2021-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}