{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:38:46Z","timestamp":1790116726842,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>MicroRNAs (miRNAs), a type of non\u2010coding RNA, have been demonstrated to be essential posttranscriptional modulators in oral diseases and inflammatory responses. However, the specific role of miR\u201027a\u20105p in periodontitis requires further investigation. In this study, we used both cellular and animal models to determine how miR\u201027a\u20105p affects the pathogenesis of periodontitis and its associated biological functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Quantitative real\u2010time polymerase chain reaction and western blotting were used to analyze the expression of cytokines, phosphatase and tensin homolog deleted on chromosome ten (PTEN), and miR\u201027a\u20105p transcription. Investigation of alveolar bone resorption and inflammation of the periodontium in ligature\u2010induced periodontitis in mice was performed using micro\u2010computed tomography (micro\u2010CT), hematoxylin\u2010eosin (HE) staining, and tartrate\u2010resistant acid phosphatase (TRAP) staining. The binding of miR\u201027a\u20105p and PTEN was predicted using the TargetScan database and experimentally confirmed using dual luciferase reporter gene assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The inflamed gingiva showed lower levels of miR\u201027a\u20105p. Macrophages from <jats:italic>miR\u201027a\u20105p<\/jats:italic><jats:sup>\u2013\/\u2013<\/jats:sup> mice produced much higher quantities of pro\u2010inflammatory cytokines owing to the stimulation of <jats:italic>Porphyromonas gingivalis<\/jats:italic> lipopolysaccharide, and <jats:italic>miR\u201027a\u20105p<\/jats:italic><jats:sup>\u2013\/\u2013<\/jats:sup> mice with ligature\u2010induced periodontitis also exhibited more severe alveolar bone resorption and damage to the periodontium. Target validation assays identified PTEN as a direct target of bona. Blocking PTEN expression partially reduced inflammation, both in vitro and in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>miR\u201027a\u20105p alleviated the inflammatory response in periodontitis by targeting PTEN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/omi.12416","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T20:56:20Z","timestamp":1684788980000},"page":"309-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["miR\u201027a\u20105p alleviates periodontal inflammation by targeting phosphatase and tensin homolog deleted on chromosome ten"],"prefix":"10.1111","volume":"38","author":[{"given":"Li","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Periodontics Stomatological Hospital and Dental School of Tongji University Shanghai Engineering Research Center of Tooth Restoration and Regeneration  Shanghai 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