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The oral cavity contains diverse microorganisms that inhabit various niches such as the oral microbial \u201cbiomap.\u201d It does not seem specific enough to establish a characteristic microbiome, given the diversity of clinical manifestations, variable rates of salivary secretion, and influential risk factors in patients with SS. This review discusses the biogeography of the oral microbiome in patients with SS such as saliva, tongue, tooth, mucosa, and gum. The microorganisms that were more abundant in the different oral niches were Gram\u2010positive species, suggesting a higher survival of cell wall bacteria in this arid oral environment. Reduced salivary flow appears not to be linked to the cause of dysbiosis alone but influences host\u2010associated risk factors. However, much work remains to be done to establish the role of the microbiome in the etiopathogenesis of autoimmune diseases such as SS. Future studies of the microbiome in autoimmunity will shed light on the role of specific microorganisms that have never been linked before with SS.<\/jats:p>","DOI":"10.1111\/omi.12435","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T08:03:47Z","timestamp":1695888227000},"page":"400-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oral microbial <i>biomap<\/i> in the drought environment: Sjogren's syndrome"],"prefix":"10.1111","volume":"38","author":[{"given":"Laura","family":"Bustos\u2010Lobato","sequence":"first","affiliation":[{"name":"Facultad de Odontolog\u00eda Departamento de Estomatolog\u00eda Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Rus","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda Departamento de Estomatolog\u00eda Universidad de Sevilla  Sevilla 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