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The etiology of these conditions is not fully understood but inflammation appears to play a significant role. Periodontal diseases have been associated with conditions such as stroke and dementia, which are clinical consequences of CSVD. Periodontitis is a highly prevalent chronic multifactorial inflammatory disease regulated by the host immune response against pathogenic bacterial colonization around the teeth. The inflammatory response and the microbial dysbiosis produce pro\u2010inflammatory cytokines that can reach the brain and promote local changes. This review will explore the potential association between periodontitis and CSVD by assessing the impact of periodontitis\u2010induced inflammation and periodontopathogenic bacteria on the underlying mechanisms leading to CSVD. Given the association of periodontitis with stroke and dementia, which are clinical features of CSVD, it may be possible to suggest a link with CSVD. Current evidence linking periodontitis with neuroimaging findings of CSVD enforces the possible link between these conditions.<\/jats:p>","DOI":"10.1111\/omi.12443","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T06:59:44Z","timestamp":1699253984000},"page":"190-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The potential impact of periodontitis on cerebral small vessel disease"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1686-6450","authenticated-orcid":false,"given":"Beatriz","family":"Bezerra","sequence":"first","affiliation":[{"name":"Section of Periodontics UCLA School of Dentistry  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Neurology UC Irvine Medical Center  Orange California 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