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Numerous clinical studies have linked\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    with unfavorable prognostic outcomes in various malignancies. In further research, scholars have partially elucidated the mechanisms underlying\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    \u2019s impact on various types of cancer, thus gaining a certain comprehension of the role played by\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    in cancer. In this comprehensive review, we present an in\u2010depth synthesis of the interplay between\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    and different cancers, focusing on aspects such as tumor initiation, metastasis, chemoresistance, and modulation of the tumor immune microenvironment and immunotherapy. The implications for cancer diagnosis and treatment are also summarized. 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