{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:02:46Z","timestamp":1785884566029,"version":"3.56.0"},"reference-count":158,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clustered regularly interspaced short palindromic repeats (CRISPRs) are DNA sequences capable of editing a host genome sequence. CRISPR and its specific CRISPR\u2010associated (Cas) protein complexes have been adapted for various applications. These include activating or inhibiting specific genetic sequences or acting as molecular scissors to cut and modify the host DNA precisely. CRISPR\u2010Cas systems are also naturally present in many oral bacteria, where they aid in nutrition, biofilm formation, inter\u2010 and intraspecies communication (quorum sensing), horizontal gene transfer, virulence, inflammation modulation, coinfection, and immune response evasion. It even functions as an adaptive immune system, defending microbes against invading viruses and foreign genetic elements from other bacteria by targeting and degrading their DNA. Recently, CRISPR\u2010Cas systems have been tested as molecular editing tools to manipulate specific genes linked with periodontal disease (such as periodontitis) and as novel methods of delivering antimicrobial agents to overcome antimicrobial resistance. With the rapidly increasing role of CRISPR in treating inflammatory diseases, its application in periodontal disease is also becoming popular. Therefore, this review aims to discuss the different types of CRISPR\u2010Cas in oral microbes and their role in periodontal disease pathogenesis and precision periodontal therapy.<\/jats:p>","DOI":"10.1111\/omi.12483","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T03:40:14Z","timestamp":1725334814000},"page":"1-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of CRISPR\u2010Cas systems in periodontal disease pathogenesis and potential for periodontal therapy: A review"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4805-5943","authenticated-orcid":false,"given":"Aditi","family":"Chopra","sequence":"first","affiliation":[{"name":"Department of Periodontology Manipal College of Dental Sciences, Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Bhuvanagiri","sequence":"additional","affiliation":[{"name":"Department of Periodontology Manipal College of Dental Sciences, Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kshitija","family":"Natu","sequence":"additional","affiliation":[{"name":"School of Dentistry University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7706-3577","authenticated-orcid":false,"given":"Avneesh","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Oral Medicine and Oral Surgery Institute for Dental and Craniofacial Sciences, Charit\u00e9\u2013University Medicine Berlin, Corporate member of Freie Universit\u00e4t Berlin, Humboldt\u2013Universit\u00e4t zu Berlin, and Berlin Institute of Health  Berlin Germany"},{"name":"Manipal College of Dental Sciences, Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24049"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4317\/MEDORAL.23008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MICPATH.2019.03.036"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRMICRO.2015.14"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1157358"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/21025.8864"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/OMI.12017"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01727\u201014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M502041200"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TIM.2016.12.012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/JRE.12846"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1138140"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MOLCEL.2014.03.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/PRD.12322"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/OMI.12278"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010014\u20100516\u2010x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025239"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JOEN.2012.07.004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00261\u201015"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00275\u201017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574\u20106976.12085"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01411\u201010"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.YMPEV.2010.05.020"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARCHORALBIO.2017.07.023"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2019.1638196"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3402\/JOM.V7.29008"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/FCIMB.2017.00028"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1574\u20106968.2006.00426.X"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462\u20102920.13123"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13148\u2010021\u201001074\u2010W"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211017510"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3011"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1231143"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AAQ0180\/SUPPL_FILE\/AAQ0180\u2010COX\u2010SM.PDF"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1099\/00207713\u201030\u20103\u2010559\/CITE\/REFWORKS"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1914073"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00035\u201013\/ASSET\/52289636\u20106E6B\u20104F29\u201095AA\u2010EB9D096263D5\/ASSETS\/GRAPHIC\/ZMR9990923500008.JPEG"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/OMI.12204"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1258096"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.25.4.389\u2010413.1933"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2014.155"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2020.11.012"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520963710"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1099\/00207713\u201051\u20103\u20101179"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519875443"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/V13101964"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2020.1775333"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TIBTECH.2013.04.004"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00239\u2010005\u20100223\u2010Z"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/OMI.12247"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/OMI.12279"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72992"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/OMI.12065"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101894\u20108"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2012.04.003"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2014.05.010"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2647"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.ADD5064\/SUPPL_FILE\/SCIENCE.ADD5064_MDAR_REPRODUCIBILITY_CHECKLIST.PDF"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467\u2010018\u201005092\u2010W"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10142\u2010017\u20100550\u20103"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AAL5056\/ASSET\/49F8637F\u201049FF\u201045ED\u2010BE45\u20109BCCD71BBBF1\/ASSETS\/GRAPHIC\/356_AAL5056_FA.JPEG"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV\u2010BIOPHYS\u2010062215\u2010010822"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1225829"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1247997"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00676"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MOLCEL.2009.12.033"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/JCP.27972"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1099\/MIC.0.27589\u20100"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-42990-4_7"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/JCM8081135"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/GBE\/EVX192"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1902\/JOP.2008.080213"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4192"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.10.030"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.62.4.1244\u20101263.1998"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1600\u20100757.2009.00329.X"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.03015"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2016.135"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOACTMAT.2020.02.012"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.syapm.2011.05.002"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12934\u2010020\u201001431\u2010Z"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1600\u2010051X.1992.TB00448.X"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10096\u2010012\u20101733\u20104"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/PBI.12256"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745\u20106150\u20107\u201040\/FIGURES\/4"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2577"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRMICRO3569"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOCEL.2014.05.015"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515611876"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.2c00649"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1101\/GR.150433.112"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102958.1993.tb01721.x"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211049984"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41431\u2010018\u20100265\u20105"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/HMG\/DDY015"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102180\u201014\u2010175"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/DNARES\/DSN013"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.18.5591\u20105601.2003"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/FCIMB.2020.619763\/BIBTEX"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.02.001"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1600\u20100765.1997.TB00937.X"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2021.03.025"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FEMSRE.2004.09.001"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1128\/MBIO.00227\u201010"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010019\u20100064\u2010z"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365\u20102958.2010.07482.X"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010019\u20100131\u20105"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574\u20106968.12320"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/ISMEJ.2011.169"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1101\/GR.111732.110"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2013.02.022"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.143"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOCHI.2015.03.025"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PGEN.1002441"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/ISMEJ.2013.63"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01454\u201019"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.5772\/67789"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400110"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1099\/IJS.0.64192\u20100"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12048"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1128\/MICROBIOLSPEC.PLAS\u20100034\u20102014"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329672"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.02333\u201014"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRMICRO.2016.184"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467\u2010019\u201010630\u20101"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1128\/MSYSTEMS.00852\u201020"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1793"},{"key":"e_1_2_9_130_1","doi-asserted-by":"crossref","unstructured":"Sorek R. Lawrence C. M. &Wiedenheft B.(2013).CRISPR\u2010mediated adaptive immune systems in Bacteria and Archaea.82 237\u2013266.https:\/\/doi.org\/10.1146\/ANNUREV\u2010BIOCHEM\u2010072911\u2010172315","DOI":"10.1146\/annurev-biochem-072911-172315"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.3748\/WJG.V22.I3.1034"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TIG.2010.05.008"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1099\/IJS.0.02277\u20100"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1046\/J.1365\u20102958.2002.02892.X"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARCHORALBIO.2019.01.016"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M109.047472"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/JCPE.12154"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TIM.2015.12.011"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1462\u20102920.2007.01444.X"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598\u2010021\u201087016\u20101"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.3.1170\u20101178.2003"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkac166"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S418099"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.05269\u201011"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1093\/GBE\/EVT075"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0183752"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/IJC.29626"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3241"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.30.9.2225\u20102229.1992"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBRC.2019.03.206"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11082060"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41556\u2010019\u20100425\u2010Z"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13073\u2010015\u20100153\u20103"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.3389\/FBIOE.2020.575393\/BIBTEX"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518805978\/ASSET\/IMAGES\/LARGE\/10.1177_0022034518805978\u2010FIG6.JPEG"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2014.11.052"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/JRE.12535"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/S13238\u2010015\u20100182\u20100"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M80140820010.1074\/jbc.M801408200"}],"container-title":["Molecular Oral Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/omi.12483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:02:24Z","timestamp":1736121744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/omi.12483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":158,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/omi.12483"],"URL":"https:\/\/doi.org\/10.1111\/omi.12483","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/OMI.12483\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12483\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12483\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/OMI.12483\/v1\/review1","asserted-by":"object"}]},"ISSN":["2041-1006","2041-1014"],"issn-type":[{"value":"2041-1006","type":"print"},{"value":"2041-1014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,3]]},"assertion":[{"value":"2024-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}