{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:34:17Z","timestamp":1790696057768,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the characteristics of the salivary microbiome in Type 2 diabetes mellitus (T2DM) patients with or without periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Periodontitis has been identified as clear sequelae of T2DM. This chronic oral disease also impacts the management of the clinical features of diabetes. The oral microbiome characteristics in T2DM with and without periodontitis, as well as the response of this oral microbiome to nonsurgical therapy have not been well described. Knowledge of key oral biological features could help address the observed poorer clinical presentation of T2DM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The oral microbiome in saliva of adult cohorts periodontally healthy\/non\u2010diabetic (non\u2010periodontitis; NP;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a031), T2DM without periodontitis (DWoP;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a032), and T2DM with periodontitis (DWP;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a029) were characterized by microbial molecular analysis using V3\u2013V4 sequencing and Luminex or ELISA techniques for salivary host analytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Phyla distribution showed DWP with significantly lower levels of\n                      <jats:italic>Firmicutes<\/jats:italic>\n                      and\n                      <jats:italic>Actinobacteria<\/jats:italic>\n                      and higher levels of\n                      <jats:italic>Fusobacteria<\/jats:italic>\n                      and\n                      <jats:italic>Spirochetes<\/jats:italic>\n                      compared to the healthier groups. Approximately 10% of the detected microbial species showed significant differences in frequency and level of colonization among the DWP, DWoP, and NP samples. A subset of bacteria were significantly correlated with clinical disease features, as well as a specific repertoire of salivary analytes, in particular matrix metalloproteinase (MMP)8\/MMP9, interleukin\u20101\u00df, B\u2010cell activating factor, and resistin differed between the groups and were related to specific taxa. Principal component analysis that identified a majority of the DWP subjects microbiome was unique based upon an array of 27 taxa out of up to 255 detected in the saliva samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>T2DM patients with periodontitis show unique oral microbiome and salivary analyte composition compared to diabetics or non\u2010diabetic persons without periodontitis. Specific members of the oral microbiome relate directly to the clinical disease features and\/or salivary biomolecules in T2DM individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/omi.12485","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T04:15:55Z","timestamp":1727756155000},"page":"37-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Salivary microbiome and biomarker characteristics of diabetics with periodontitis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9743-6585","authenticated-orcid":false,"given":"Jeffrey L.","family":"Ebersole","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences School of Dental Medicine University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenatha S.","family":"Kirakodu","sequence":"additional","affiliation":[{"name":"Center for Oral Health Research College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiahou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Dolph","family":"Dawson","sequence":"additional","affiliation":[{"name":"Center for Oral Health Research College of Dentistry University of Kentucky  Lexington Kentucky USA"},{"name":"Department of Oral Health Practice Center for Oral Health Research of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig S.","family":"Miller","sequence":"additional","affiliation":[{"name":"Center for Oral Health Research College of Dentistry University of Kentucky  Lexington Kentucky USA"},{"name":"Department of Oral Health Practice Center for Oral Health Research of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13183"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20\u20100406"},{"key":"e_1_2_10_4_1","volume-title":"Diagnosis","author":"American Diabetes Association","year":"2022"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.8.1237"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2021.10.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010022\u201000183\u20103"},{"issue":"7","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1177\/154405910808700707","article-title":"Salivary procalcitonin and periodontitis in diabetes","volume":"87","author":"Bassim C. 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