{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:14:06Z","timestamp":1791983646743,"version":"4.4.0"},"reference-count":141,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2024ZD1000600"],"award-info":[{"award-number":["2024ZD1000600"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Streptococcus mutans<\/jats:italic>\n                    , the principal pathogen associated with dental caries, impacts individuals across all age groups and geographic regions. Beyond its role in compromising oral health, a growing body of research has established a link between\n                    <jats:italic>S. mutans<\/jats:italic>\n                    and various systemic diseases, including immunoglobulin A nephropathy (IgAN), nonalcoholic steatohepatitis (NASH), infective endocarditis (IE), ulcerative colitis (UC), cerebral hemorrhage, and tumors. The pathogenic mechanisms associated with\n                    <jats:italic>S. mutans<\/jats:italic>\n                    frequently involve collagen\u2010binding proteins (CBPs) and protein antigens (PA) present on the bacterial surface. These components facilitate intricate interactions with the host immune system, thereby potentially contributing to various pathological processes. Specifically, CBP is implicated in the deposition of IgA and complement component C3, which exhibits characteristics reminiscent of IgAN\u2010like lesions through animal models, recent clinical studies suggest a potential involvement of\n                    <jats:italic>S. mutans<\/jats:italic>\n                    in IgAN. In addition, CBP binds to complement component C1q, effectively inhibiting the classical activation pathway of the complement system. In addition, CBP promotes the induction of host cells to produce interferon\u2010gamma (IFN\u2010\u03b3). Furthermore, CBP leads to direct inhibitory effects on platelets and the activation of matrix metalloproteinase\u20109 (MMP\u20109) at sites of vascular injury.\u00a0Moreover, PA enhances the ability of\n                    <jats:italic>S. mutans<\/jats:italic>\n                    to invade hepatic tissue. Through utilization of its PAc,\n                    <jats:italic>S. mutans<\/jats:italic>\n                    excessively produces kynurenine (KYNA), which promotes the development and progression of oral squamous cell carcinoma (OSCC). This article synthesizes the latest advancements in understanding the mechanisms of intricate interactions between\n                    <jats:italic>S. mutans<\/jats:italic>\n                    and various systemic conditions in humans, expanding our perspective beyond the traditional focus on dental caries.\n                  <\/jats:p>","DOI":"10.1111\/omi.12491","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T03:29:39Z","timestamp":1737948579000},"page":"65-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["From Teeth to Body: The Complex Role of\n                    <i>Streptococcus mutans<\/i>\n                    in Systemic Diseases"],"prefix":"10.1111","volume":"40","author":[{"given":"Haowen","family":"Xiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-6300","authenticated-orcid":false,"given":"Yuqing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China"},{"name":"Center for Archaeological Science Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00767\u201010"},{"issue":"3","key":"e_1_2_14_3_1","first-page":"408","article-title":"Streptococcus mutans\u2010Induced Nephritis in Rabbits","volume":"118","author":"Albini B.","year":"1985","journal-title":"American Journal of 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