{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:45:51Z","timestamp":1791999951832,"version":"4.4.0"},"reference-count":229,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Periodontitis (periodontal disease [PD]) is a complex inflammatory disease caused by a polymicrobial infection that facilitates the destruction of the connective tissue and bone that support the teeth. PD is highly correlated with cardiovascular disease, low birth weight, preterm osteoporosis, Alzheimer's disease, and rheumatoid arthritis. <jats:italic>Porphyromonas gingivalis<\/jats:italic>, a main causative agent of PD, is a non\u2010motile, asaccharolytic, Gram\u2010negative bacterium identified in subgingival, supragingival, and tongue sites in patients. <jats:italic>P. gingivalis<\/jats:italic> produces an arsenal of virulence factors, which include fimbriae, lipopolysaccharide (LPS), gingipains and other proteases, <jats:italic>P.\u00a0gingivalis<\/jats:italic> peptidyl arginine deiminase (PPAD), and others. Recently, a number of reports highlighted novel aspects of <jats:italic>P. gingivalis<\/jats:italic> virulence. LPS signaling via Toll\u2010like receptor 2 (TLR2) and Toll\u2010like receptor 4 (TLR4) was elucidated; outer membrane vesicles (OMVs) were implicated as the shuttle for inflammatory induction and neurotoxicity, and gingipains were found to disrupt the integrity of blood\u2013brain barrier (BBB). Further, Tpr protease substrate specificity was described in detail, a novel variant of PPAD was identified and correlated with the aggressive disease, and the role of C\u2010terminal domain as the substrate for the Type IX secretion system (T9SS) transport has been unveiled, together with the identification of the first T9SS inhibitors. The impact of the COVID\u201019 pandemic prompted the novel research, expanding our understanding of the <jats:italic>P. gingivalis<\/jats:italic> correlation with viral infections. These recent findings implicate the need to update the current knowledge of the <jats:italic>P. gingivalis<\/jats:italic> virulence factors and provide a comprehensive review of the current trends in <jats:italic>P. gingivalis<\/jats:italic> research.<\/jats:p>","DOI":"10.1111\/omi.12496","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T09:49:03Z","timestamp":1749030543000},"page":"159-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>Porphyromonas gingivalis<\/i>: Multiple Tools of an Inflammatory Damage"],"prefix":"10.1111","volume":"40","author":[{"given":"Hlafira","family":"Polishchuk","sequence":"first","affiliation":[{"name":"Faculty of Biochemistry, Biophysics and Biotechnology Department of Microbiology Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9846-6922","authenticated-orcid":false,"given":"Aleksandra","family":"Synowiec","sequence":"additional","affiliation":[{"name":"Faculty of Biochemistry, Biophysics and Biotechnology Department of Microbiology Jagiellonian University  Krakow Poland"},{"name":"Malopolska Centre of Biotechnology Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Zubrzycka","sequence":"additional","affiliation":[{"name":"Faculty of Biochemistry, Biophysics and Biotechnology Department of Microbiology Jagiellonian University  Krakow Poland"},{"name":"Malopolska Centre of Biotechnology Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3023-2382","authenticated-orcid":false,"given":"Tomasz","family":"Kantyka","sequence":"additional","affiliation":[{"name":"Malopolska Centre of Biotechnology Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23080"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.174"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287\u2010146\u20108\u20101933"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph110706979"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11101173"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201032603\u2010y"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100757.2010.00376.x"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106968.2000.tb09405.x"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100757.2010.00359.x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.6.972"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3571"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1355357"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1183415"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C114.617142"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.1986.tb01478.x"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00599\u201024"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106968.2012.02579.x"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007773"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.139388"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201302600411"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01017"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010019\u20100604\u20102"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1438272"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519865184"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11020470"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200811200"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2024.04.002"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03787\u201021"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462\u20105822.2009.01349.x"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00187\u201015"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae209"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00485"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574\u20106976.12056"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.1999.tb02282.x"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2337"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00048"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen\u20102024\u2010005111"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010020\u20100788\u20108"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3106"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425912450348"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau3333"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00753\u201022"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.20.5453"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00031\u201009"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v5i0.20265"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520943187"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2009.309"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517747575"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049\u20102618\u20102\u201032"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12081"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201009412\u2010w"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.369223"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.925435"},{"key":"e_1_2_14_55_1","doi-asserted-by":"crossref","unstructured":"Gorasia D. G.Chreifi C.Seers et\u00a0al.2020. \u201cIn Situ Structure and Organisation of the Type IX Secretion System.\u201d bioRxiv.https:\/\/doi.org\/10.1101\/2020.05.13.094771.","DOI":"10.1101\/2020.05.13.094771"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105681"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005152"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11969"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.8.4742\u20104748.2003"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01956\u201021"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12134"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100757.2010.00377.x"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.03.008"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.2741\/2409"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12161"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2359"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2021.09.003"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.185744"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010020\u201000823\u20106"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20101097(03)00788\u20102"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz\u20102018\u20100215"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00053"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20109969(84)90043\u20108"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139454"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.1.111"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102249.2006.03156.x"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.07.012"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006594"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102019\u2010216919"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00262"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23288"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.08.004"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2025.2479903"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.108166"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.3233\/ADR\u2010200250"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2016.117"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2009.136"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/fty033"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509338032"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005580"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01170\u201013"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u2010302X.2007.00335.x"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266\u2010006\u20100060\u20106"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890\u2010019\u20101017\u20101"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154182"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080213"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926\u2010014\u20100408\u20109"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00884\u201016"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.091208.073413"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.8.2098\u20102106.1995"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.1994.1081"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31138"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA119.001700"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100693\u2010y"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13966"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1556\/EuJMI.1.2011.1.7"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2021.01.003"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2022.2123550"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12334"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010024\u201000313\u2010z"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009808"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.42.2.659\u2010667.1983"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.11.5147\u20105156.1998"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.01.006"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.1.238\u2010247.1995"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201088518\u2010y"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.05.012"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663\u2010009\u20100028\u20105"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201037534\u2010x"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.4.1052\u20101059.1994"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134576"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.221"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.11.1987"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.7.3248\u20103256.1999"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050459"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.681810"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211\u20105463.13066"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2103573118"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.230448"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.047"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2017.1281562"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519898144"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043722"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510370089"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026163"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2013.10.005"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348\u20100421.1997.tb01189.x"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.18.12245"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1998.2708"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2011.208"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.18.5591\u20105601.2003"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102958.2004.04291.x"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2006\/005561\u20100"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2022.105282"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u2010302x.1991.tb00504.x"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021426"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.33.21225"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2020.1820834"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2018.1487742"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.1.117\u2010123.1993"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.001320"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12073"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.3.1101\u20101104.1997"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20101097(92)90721\u2010y"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.10.4139\u20104146.1993"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.1982.tb01138.x"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.3.1595"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.3.1007"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)42365-9"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.10.2876\u20102882.1996"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5396.2085"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100757.2000.2240108.x"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.34.21648"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1515\/bchm.1997.378.3\u20104.223"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1159\/000181144"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203033487036"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41415\u2010019\u20100794\u20105"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00830\u201012"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102012\u2010202726"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.1982.tb01154.x"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2105170118"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmicr.2024.100249"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820130500496811"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41429\u2010024\u201000790\u20108"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14083"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912010107"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413544200"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2014.06.005"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202350776"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2021.105201"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep05056"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287\u2010144\u20106\u20101583"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12149"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00197"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9070530"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1998.tb02419.x"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2005.01.006"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2119907119"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39313"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/750479"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.648782"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2020_6904"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(01)05321\u20101"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01704\u201018"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2010.06.005"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00133\u201020"},{"key":"e_1_2_14_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.12.003"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909546117"},{"key":"e_1_2_14_200_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.01705\u201021"},{"key":"e_1_2_14_201_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102643"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr401227e"},{"key":"e_1_2_14_203_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13752"},{"key":"e_1_2_14_204_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr400487b"},{"key":"e_1_2_14_205_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01497\u201020"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231710011"},{"key":"e_1_2_14_207_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00343\u201020"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522\u2010019\u20100081\u2010x"},{"key":"e_1_2_14_209_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.765081"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106968.2002.tb11231.x"},{"key":"e_1_2_14_211_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.01390\u201015"},{"key":"e_1_2_14_212_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2349"},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300204"},{"key":"e_1_2_14_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0003\u20109969(98)00056\u20109"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113433"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27552"},{"key":"e_1_2_14_217_1","volume-title":"Global Oral Health Status Report: Towards Universal Health Coverage for Oral Health by 2030","author":"WHO","year":"2022"},{"key":"e_1_2_14_218_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012821"},{"key":"e_1_2_14_219_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.823685"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1476001"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.9.2225\u20102229.1992"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2019.12.001"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14413"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.160.3.949\u2010957.1984"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.12.5181\u20105189.1993"},{"key":"e_1_2_14_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fmre.2021.02.003"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2022.12.003"},{"key":"e_1_2_14_228_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2014.999567"},{"key":"e_1_2_14_229_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c17748"},{"key":"e_1_2_14_230_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.585917"}],"container-title":["Molecular Oral Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/omi.12496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T08:30:46Z","timestamp":1756888246000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/omi.12496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":229,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/omi.12496"],"URL":"https:\/\/doi.org\/10.1111\/omi.12496","archive":["Portico"],"relation":{},"ISSN":["2041-1006","2041-1014"],"issn-type":[{"value":"2041-1006","type":"print"},{"value":"2041-1014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,4]]},"assertion":[{"value":"2025-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}