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Cells undergoing EMT exhibit enhanced motility, aggressiveness, and stemness, contributing to a pro\u2010tumor environment that facilitates malignant metastasis in cancer. Numerous studies have suggested that oral microbes facilitate carcinogenesis through EMT. Oral microbes can directly initiate EMT by adhering to mucosal layers and provoking the disintegration of intercellular adhesion among epithelial cells, thereby modifying cell polarity and downstream signaling pathways. Indirectly, the microbial metabolites and associated compounds can affect the dynamics of EMT. This review summarizes the mechanisms by which oral microbes regulate EMT and thus contribute significantly to cancer. Elucidating the mechanisms underlying the increased plasticity of cancer cells induced by the oral microbiota will facilitate the development of novel targeted therapeutic strategies.<\/jats:p>","DOI":"10.1111\/omi.70001","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T07:14:23Z","timestamp":1752563663000},"page":"191-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of Oral Microbes in Epithelial\u2010Mesenchymal Transition in Cancer Progression"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4279-7420","authenticated-orcid":false,"given":"Divya","family":"Gopinath","sequence":"first","affiliation":[{"name":"Basic Medical and Dental Sciences Department, College of Dentistry Ajman University Ajman UAE"},{"name":"Centre of Medical and Bio\u2010allied Health Sciences Research, Ajman University Ajman UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengrui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral and Cranio\u2010Maxillofacial Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University Shanghai China"},{"name":"National Center for Stomatology Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7101-1239","authenticated-orcid":false,"given":"Marwan Mansoor","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniofacial Health Sciences College of Dental Medicine University of Sharjah Sharjah UAE"},{"name":"Microbiota Research Group, Research Institute for Medical and Health Sciences University of Sharjah Sharjah UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swagatika","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Institute of Dental Sciences Siksha' O' Anusandhan, deemed to be University Bhubaneswar Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12546"},{"issue":"2","key":"e_1_2_9_3_1","first-page":"127","article-title":"Periodontal Pathogens Promote Epithelial\u2010Mesenchymal Transition in Oral Squamous Carcinoma Cells in Vitro","volume":"12","author":"Abdulkareem A. 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