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Fourteen two\u2010component signal transduction systems (TCSs) in\n                    <jats:italic>S. mutans<\/jats:italic>\n                    have been reported to regulate a broad range of physiological processes such as bacterial biofilm formation, acid resistance, competence development, and toxic oxygen metabolite resistance. These systems collectively contribute to the cariogenicity of\n                    <jats:italic>S. mutans<\/jats:italic>\n                    by coordinating adaptive responses to environmental challenges. Among them, the VicRK system has been one of the most extensively studied, with epidemiological evidence linking\n                    <jats:italic>vicK<\/jats:italic>\n                    mutations to increased caries risk in children. Other TCSs, such as ComDE, LiaRS, CiaRH, and the orphan response regulator GcrR, also contribute to cariogenicity regulation. The present review summarizes the regulatory roles of TCSs in virulence traits of\n                    <jats:italic>S. mutans<\/jats:italic>\n                    , with an emphasis on those involved in biofilm formation, which highlights their potential as therapeutic targets to prevent dental caries through biofilm inhibition.\n                  <\/jats:p>","DOI":"10.1111\/omi.70006","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T12:49:31Z","timestamp":1756298971000},"page":"243-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Harnessing the Regulatory Effects of\n                    <i>Streptococcus mutans<\/i>\n                    Two\u2010Component Signal Transduction Systems for Therapeutic Interventions Against Dental Caries"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8484-247X","authenticated-orcid":false,"given":"Bingrun","family":"Qiu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases Frontier Innovation Center for Dental Medicine Plus Department of Preventive Dentistry West China Hospital of Stomatology, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases Frontier Innovation Center for Dental Medicine Plus Department of Preventive Dentistry West China Hospital of Stomatology, Sichuan University  Chengdu 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