{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:06:37Z","timestamp":1791846397260,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771105"],"award-info":[{"award-number":["81771105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471008"],"award-info":[{"award-number":["82471008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Given the pivotal role of macrophages in both the progression and regenerative phases of periodontitis, targeting macrophage\u2010mediated immunity represents a novel therapeutic strategy for periodontitis management. Ubiquitin carboxyl\u2010terminal hydrolase L1 (UCHL1) has been previously implicated in inflammatory processes. However, how UCHL1 regulates macrophage immune response in periodontitis remains to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ligature\u2010induced periodontitis mice and\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      lipopolysaccharide (P.g LPS) were used to investigate the expression of UCHL1 in macrophages during immune responses. Lentivirus and an inhibitor were conducted to determine the role of UCHL1 in the periodontitis\u2010associated macrophage immune response. The mitochondrial function and the endoplasmic reticulum status of macrophages were examined to elucidate the underlying mechanisms. Finally, we constructed hydrogels containing UCHL1 inhibitor and evaluated their efficacy in treating periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The expression of UCHL1 was upregulated in proinflammatory immune response of periodontitis\u2010associated macrophages. Inhibition of UCHL1 reduced the expression and release of TNF\u2010\u03b1, IL\u20106, and IL\u20101\u03b2. In addition, inhibition of UCHL1 in macrophages improved the osteogenesis and migration ability of MC3T3\u2010E1 cells in the co\u2010culture system. Mechanistically, inhibition of UCHL1 ameliorated LPS\u2010induced mitochondrial damage and endoplasmic\u00a0reticulum\u00a0stress in macrophages. LDN@GelMA hydrogel had great in vitro anti\u2010inflammatory and bone\u2010promoting effects. Periodontal injection of LDN@GelMA hydrogel alleviated local inflammation and promoted alveolar bone regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggest that UCHL1 may serve as a critical negative regulator for periodontitis treatment, and inhibition of UCHL1 is expected to improve the periodontal inflammatory microenvironment and promote alveolar bone regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/omi.70028","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:35:02Z","timestamp":1775043302000},"page":"201-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["UCHL1 Exacerbates Periodontitis by Coordinating Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Macrophages"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5936-7008","authenticated-orcid":false,"given":"Yun","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Jiao Tong University  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology  Shanghai China"},{"name":"Research Unit of Oral and Maxillofacial Regenerative Medicine Chinese Academy of Medical Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4005-5746","authenticated-orcid":false,"given":"Shengjia","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Jiao Tong University  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology  Shanghai China"},{"name":"Research Unit of Oral and Maxillofacial Regenerative Medicine Chinese Academy of Medical Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9906-9221","authenticated-orcid":false,"given":"Hanxiao","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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