{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:21:27Z","timestamp":1788340887961,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The oral\u2010derived pathobiont\n                    <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    has increasingly been implicated in colorectal cancer (CRC) progression through its ability to modulate inflammatory, immunological, and molecular pathways.\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    has emerged as a key oral\u2010derived pathobiont frequently associated with tumor aggressiveness and alterations in the colorectal tumor microenvironment. This review critically examines recent mechanistic evidence from in vitro, in vivo, and advanced experimental models to elucidate how\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    interacts with host pathways involved in colorectal carcinogenesis. Available evidence indicates that this bacterium actively reshapes the tumor microenvironment through coordinated effects on immune signaling, epigenetic regulation, metabolic adaptation, and metastatic competence. Mechanistically,\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    promotes sustained inflammatory activation, macrophage polarization, epithelial\u2013mesenchymal transition, endothelial remodeling, and resistance to regulated cell death pathways, while also influencing transcriptional and oncogenic programs associated with tumor progression. Emerging evidence further suggests that microbial effects may be modulated by tumor heterogeneity and long\u2010term environmental exposures, reinforcing the complexity of host\u2013microbiome interactions in CRC. Collectively, the findings support the concept that\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    functions as an active biological driver rather than a passive microbial bystander in CRC progression. These insights highlight the translational relevance of tumor\u2010associated microbiota and support the need for approaches combining mechanistic, microbial, and clinical data to refine precision strategies at the tumor\u2013microbiome interface.\n                  <\/jats:p>","DOI":"10.1111\/omi.70038","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T13:55:17Z","timestamp":1787147717000},"page":"258-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Host\u2013Microbe Mechanisms of\n                    <i>Fusobacterium nucleatum<\/i>\n                    in Colorectal Cancer"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-5188","authenticated-orcid":false,"given":"Hadda Lyzandra Austr\u00edaco","family":"Leite","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5818-412X","authenticated-orcid":false,"given":"Fernanda Ferreira","family":"Lopes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12426"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010023\u201000963\u20106"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010018\u20100129\u20106"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.860149"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.13"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal2380"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2022.831607"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010025\u201002469\u2010x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2415490"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010024\u201001075\u20105"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.744184"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.04.226"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2295384"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.6374"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.217182"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2025.101290"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522\u2010025\u201000717\u20107"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672\u2010025\u201001796\u2010w"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00011\u201007"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010022\u201002655\u20102"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.08.019"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2024.14697"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15536"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929\u2010024\u201001097\u20104"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007182\u2010w"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2038852"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1549564"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010025\u201002133\u20107"}],"container-title":["Molecular 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