{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:10:19Z","timestamp":1788948619758,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oral Microbiology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Oral squamous cell carcinoma (OSCC) is a series global health concern.\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      (\n                      <jats:italic>P.g<\/jats:italic>\n                      ), a major pathogenic bacterium, promotes tumorigenesis and progression. Ferroptosis is also closely related to the progression of tumors. Therefore, this study aimed to investigate whether\n                      <jats:italic>P.g<\/jats:italic>\n                      cell\u2010free supernatant (Pg\u2010SN) alters ferroptosis and malignant phenotypes in OSCC cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CCK\u20108 assays were used to compare the effects of cell\u2010free Pg\u2010SN and\n                      <jats:italic>Streptococcus salivarius<\/jats:italic>\n                      cell\u2010free supernatant (Ss\u2010SN) on OSCC cell viability. Wound healing and Transwell invasion assays were then performed to assess Pg\u2010SN\u2010induced changes in the migratory and invasive abilities. Flow cytometry and fluorescence microscopy were employed to examine ferroptosis biomarkers. Transmission electron microscopy was utilized to observe mitochondrial morphology, while western blot and immunofluorescence analyses were performed to assess ferroptosis\u2010related proteins.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pg\u2010SN enhanced the proliferation, migration, and invasion of OSCC cells. In addition, Pg\u2010SN suppressed ferroptosis in OSCC cells. In comparison, Ss\u2010SN had no significant effect on RSL\u20103 induced ferroptosis and OSCC cell viability. Furthermore, mechanistic studies demonstrated that Pg\u2010SN modulated the Nrf2\/SLC7A11\/GPX4 signaling pathway and reduced reactive oxygen species (ROS) and lipid peroxidation (LPO) levels. Pg\u2010SN did not significantly alter TfR1 or ACSL4 expression, suggesting that the suppressive effect on ferroptosis may be independent of iron uptake and ACSL4\u2010dependent lipid remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study demonstrates that Pg\u2010SN modulates the Nrf2\/SLC7A11\/GPX4 signaling pathway to suppress ferroptosis and promote the progression of OSCC cells. Targeting\n                      <jats:italic>P.g<\/jats:italic>\n                      associated ferroptosis resistance may represent a potential therapeutic strategy for OSCC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/omi.70039","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:54:27Z","timestamp":1788947667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cell\u2010Free Supernatant of\n                    <i>Porphyromonas gingivalis<\/i>\n                    Promotes the Malignancy of Oral Squamous Cell Carcinoma by Suppressing Ferroptosis"],"prefix":"10.1111","author":[{"given":"Rongkun","family":"Chen","sequence":"first","affiliation":[{"name":"Yunnan Key Laboratory of Stomatology School of Stomatology Kunming Medical University  Kunming China"},{"name":"Department of Periodontology The Affiliated Hospital of Stomatology School of Stomatology Kunming Medical University  Kunming China"},{"name":"Division of Oral Pathology Faculty of Dentistry &amp; Graduate School of Medical and Dental Sciences Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Stomatology School of Stomatology Kunming Medical University  Kunming China"},{"name":"Department of Periodontology The Affiliated Hospital of Stomatology School of Stomatology Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Stomatology School of Stomatology Kunming Medical University  Kunming China"},{"name":"Department of Oral Implantology The Affiliated Hospital of Stomatology School of Stomatology Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Stomatology School of Stomatology Kunming Medical University  Kunming China"},{"name":"Department of Periodontology The Affiliated Hospital of Stomatology School of Stomatology Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Ma","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Stomatology School of Stomatology Kunming Medical University  Kunming China"},{"name":"Department of Periodontology The Affiliated Hospital of Stomatology School of Stomatology Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Ren","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Stomatology School of Stomatology Kunming Medical University  Kunming China"},{"name":"Department of Periodontology The Affiliated Hospital of Stomatology School of Stomatology Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"He","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Stomatology School of Stomatology Kunming Medical University  Kunming China"},{"name":"Department of Periodontology The Affiliated Hospital of Stomatology School of Stomatology Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"issue":"2","key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41579-023-00963-6","article-title":"The Oral Microbiome: Diversity, Biogeography and Human Health","volume":"22","author":"Baker J. 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