{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:37:43Z","timestamp":1780580263753,"version":"3.54.1"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T00:00:00Z","timestamp":1658016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Older People Nursing"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hip fractures have a huge impact in reducing the quality of life and increasing mortality. This review aims to assess the impact of daily oral supplementation of vitamin D3 plus calcium on the incidence of hip fracture in people over 65\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PRISMA guidelines were followed and RCTs that evaluated the effectiveness of daily oral supplementation of vitamin D3 plus calcium in preventing hip fracture in adults over 65\u2009years were included in the study. The databases such as Cochrane Library, Embase, Medline, PubMed, CINAHL, Web of Science and Scopus were searched from October 2019\u2010 January 2020.The Cochrane risk of bias tool was used to check the quality of the included studies. A meta\u2010analysis with fixed effect model using Review Manager (Revman 5.3) was used to analyse the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The meta\u2010analysis of seven RCTs on vitamin D3 plus calcium supplementation and hip fracture (<jats:italic>n<\/jats:italic>\u00a0=\u200912,620) identified odds ratio (OR) of 0.75; 95% Confidence interval (CI): 0.64, 0.87; <jats:italic>p<\/jats:italic>\u00a0=\u2009.0003. Daily oral supplementation of 800 IU of Vitamin D3 plus 1200\u2009mg of calcium was found more effective (<jats:italic>n<\/jats:italic>\u00a0=\u20095676 participants; OR\u00a0=\u00a00.69; 95% CI: 0.58, 0.82; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) than daily oral supplementation of 800 IU of Vitamin D3 plus 1000 mg of calcium (<jats:italic>n<\/jats:italic>\u00a0=\u20096555,OR\u00a0=\u00a01.08; 95% CI: 0.74, 1.56; <jats:italic>p<\/jats:italic>\u00a0=\u2009.70) in reducing hip fracture. A meta\u2010analysis of the seven RCTs to identify the incidence of non\u2010vertebral fracture gave the OR of 0.80; 95% CI: 0.72, 0.89; <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.0001. A meta\u2010analysis of three RCTs on femoral neck bone mineral density (BMD) (<jats:italic>n<\/jats:italic>\u00a0=\u2009483) gave a mean difference of 1.21; 95% CI: \u20100.79, 3.20; <jats:italic>p<\/jats:italic>\u00a0=\u2009.24.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Daily oral supplementation 800\u2009IU of vitamin D3 plus 1200\u2009mg of calcium reduces hip fracture and non\u2010vertebral fracture in older people. Administering vitamin D3 and calcium supplements had no effect in increasing the femoral neck BMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications for practice<\/jats:title><jats:p>Even though it is evident from the review that optimal daily intake of vitamin D3 plus calcium supplementation help in the prevention of fracture, it is only one essential element in fracture prevention. Also, people who are on dietary supplements should be compliant with same for better result. Efforts to prevent bone loss and osteoporosis should begin from an early age. It includes maintaining a healthy lifestyle, optimal intake of calcium and vitamin D3, proper nutrition, adequate exposure to sunlight, exercise etc. Proper education on healthy lifestyle, avoiding risk factors like smoking, caffeine, alcohol and awareness of bone health should continue throughout life with emphasis during menopause when increased bone loss is expected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/opn.12492","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T18:40:27Z","timestamp":1658083227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["What is the impact of daily oral supplementation of vitamin <scp>D3<\/scp> (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5408-0198","authenticated-orcid":false,"given":"Preethy","family":"Manoj","sequence":"first","affiliation":[{"name":"School of Nursing and Midwifery The Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences  Dublin 2 Ireland"},{"name":"Connolly Hospital, Blanchardstown  Dublin 15 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie","family":"Derwin","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery The Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences  Dublin 2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9843-4816","authenticated-orcid":false,"given":"Sherly","family":"George","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery The Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences  Dublin 2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2121"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000227.pub4"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-019-0804-y"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007991003659814"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.5.1780"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b3692"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.18.2257"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1098266"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6936.1081"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212033272305"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980200023"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709043371003"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1328-3"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-6618(04)00145-8"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7547.969"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.2.504"},{"key":"e_1_2_12_19_1","volume-title":"The Economic Costs of falls and fractures in people aged 65 and over in Ireland","author":"Gannon B.","year":"2007"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7292.968"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(03)00046-0"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afh002"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-3-6"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"issue":"4","key":"e_1_2_12_26_1","first-page":"185","article-title":"The effect of cholecalciferol (vitamin D 3) on the risk of fall and fracture: A meta\u2010analysis","volume":"100","author":"Jackson C.","year":"2007","journal-title":"Journal of the Association of Physicians"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055218"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-1167-8"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurpra.2007.01.017"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.2217\/WHE.10.51"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192388"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-910"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01623440"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2014.01.003"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-11-37"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/eb-2014-101794"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu2090975"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980200012"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0662-7"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7498.1003"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-2224-2"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0226-4"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u2010"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1185\/0300799019117003"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50393"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.48"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.15.1737"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.s3552"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61342-7"},{"issue":"1","key":"e_1_2_12_53_1","first-page":"738","article-title":"Calcium plus vitamin D supplementation and risk of fractures: An updated meta\u2010analysis from NOF","volume":"29","author":"Wallace T.","year":"2015","journal-title":"The FASEB Journal"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3386-5"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3390-9"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2009.12"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.17789"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19344"}],"container-title":["International Journal of Older People Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/opn.12492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/opn.12492","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/opn.12492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T04:32:37Z","timestamp":1709267557000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/opn.12492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,17]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/opn.12492"],"URL":"https:\/\/doi.org\/10.1111\/opn.12492","archive":["Portico"],"relation":{},"ISSN":["1748-3735","1748-3743"],"issn-type":[{"value":"1748-3735","type":"print"},{"value":"1748-3743","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,17]]},"assertion":[{"value":"2020-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12492"}}