{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:06:46Z","timestamp":1788869206050,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T00:00:00Z","timestamp":1423440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002790","name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["290026"],"award-info":[{"award-number":["290026"]}],"id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Conjunctival compression observed in ultrahigh resolution optical coherence tomography (\n                      <jats:styled-content style=\"fixed-case\">UHR<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      ) images of contact lens edges could be actual tissue alteration, may be an optical artefact arising from the difference between the refractive indexes of the lens material and the conjunctival tissue, or could be a combination of the two. The purpose of this study is to image the artefact with contact lenses on a non\u2010biological (non\u2010indentable) medium and to determine the origins of the observed conjunctival compression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two\u2010dimensional cross\u2010sectional images of the edges of a selection of marketed silicone hydrogel and hydrogel lenses (refractive index ranging from 1.40 to 1.43) were acquired with a research grade\n                      <jats:styled-content style=\"fixed-case\">UHR<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      system. The lenses were placed on three continuous surfaces, a glass sphere (refractive index\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01.52), a rigid contact lens (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01.376) and the cornea of a healthy human subject (average\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01.376). The displacement observed was analysed using ImageJ.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The observed optical displacement ranged between 5.39(0.06) \u03bcm with Acuvue Advance and 11.99(0.18) \u03bcm with Air Optix Night &amp; Day when the lens was imaged on the glass reference sphere. Similarly, on a rigid contact lens displacement ranged between 5.51(0.03) and 9.72(0.12) \u03bcm. Displacement was also observed when the lenses were imaged on the human conjunctiva and ranged from 6.49(0.80) \u03bcm for the 1\u2010day Acuvue Moist to 17.4(0.22) \u03bcm for the Pure Vision contact lens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      An optical displacement artefact was observed when imaging a contact lens on two rigid continuous surfaces with\n                      <jats:styled-content style=\"fixed-case\">UHR<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\n                      where compression or indentation of the surface could not have been a factor. Contact lenses imaged\n                      <jats:italic>in situ<\/jats:italic>\n                      also exhibited displacement at the intersection of the contact lens edge and the conjunctiva, likely a manifestation of both the artefact and compression of the conjunctiva.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12196","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T04:45:02Z","timestamp":1423457102000},"page":"283-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Optical edge effects create conjunctival indentation thickness artefacts"],"prefix":"10.1007","volume":"35","author":[{"given":"Luigina","family":"Sorbara","sequence":"first","affiliation":[{"name":"School of Optometry &amp; Vision Science University of Waterloo Waterloo Canada"},{"name":"Centre for Contact Lens Research University of Waterloo Waterloo Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trefford L.","family":"Simpson","sequence":"additional","affiliation":[{"name":"School of Optometry &amp; Vision Science University of Waterloo Waterloo Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotsna","family":"Maram","sequence":"additional","affiliation":[{"name":"School of Optometry &amp; Vision Science University of Waterloo Waterloo Canada"},{"name":"Centre for Contact Lens Research University of Waterloo Waterloo Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Sun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Physics &amp; Astronomy University of Waterloo Waterloo Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostadinka","family":"Bizheva","sequence":"additional","affiliation":[{"name":"School of Optometry &amp; Vision Science University of Waterloo Waterloo Canada"},{"name":"Department of Physics &amp; Astronomy University of Waterloo Waterloo Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Hutchings","sequence":"additional","affiliation":[{"name":"School of Optometry &amp; Vision Science University of Waterloo Waterloo Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2005.02.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e318199d1f7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e31805d0116"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2005.tb06661.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7177"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0141-7037(92)80031-T"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181d25ce2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12425"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb08190.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-1549(03)00103-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2004.05.024"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200104000-00009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(98)80289-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.28.001745"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1364\/OPEX.12.002404"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090240090031"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900110506"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1997.0401"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2006.00371.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.opx.0000221403.32040.17"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6507"},{"key":"e_1_2_7_23_1","unstructured":"MaramJ SimpsonT SorbaraL SongES&BizhevaK.Lens edge artefact occurring when imaged with an Ultra\u2010high resolution Optical coherence tomographer. 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