{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:12:36Z","timestamp":1785190356359,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T00:00:00Z","timestamp":1445385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["RO1 EY10213"],"award-info":[{"award-number":["RO1 EY10213"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R21 EY018370\u201001A2"],"award-info":[{"award-number":["R21 EY018370\u201001A2"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["and R21 EY018370\u201001A2S1"],"award-info":[{"award-number":["and R21 EY018370\u201001A2S1"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe an anteriorly located system of zonular fibres that could be involved in fine\u2010tuning of accommodation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010six human and 28 rhesus monkey eyes were dissected and special preparations were processed for scanning electron microscopy and reflected\u2010light microscopy. Additional series of frontal and sagittal histological and ultrathin sections were analysed in respect to the origin and insertion of anteriorly located zonules. The presence of sensory terminals at the site of the originating zonules within the connective tissue of the ciliary body was studied by immunohistochemistry. For\n                      <jats:italic>in\u2010vivo<\/jats:italic>\n                      visualization ultrasound biomicroscopy (\n                      <jats:styled-content style=\"fixed-case\">UBM<\/jats:styled-content>\n                      ) was performed on 12 human subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fine zonular fibres originated from the valleys and lateral walls of the most anterior pars plicata that covers the anterior and inner circular ciliary muscle portion. These most anterior zonules (\n                      <jats:styled-content style=\"fixed-case\">MAZ<\/jats:styled-content>\n                      ) showed attachments either to the anterior or posterior tines or they inserted directly onto the surface of the lens. At the site of origin, the course of the\n                      <jats:styled-content style=\"fixed-case\">MAZ<\/jats:styled-content>\n                      merged into the connective tissue fibres connecting the adjacent pigmented epithelium to the ciliary muscle. Numerous afferent terminals directly at the site of this\n                      <jats:styled-content style=\"fixed-case\">MAZ<\/jats:styled-content>\n                      \u2010origin were connected to the intrinsic nervous network of the ciliary muscle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A newly described set of zonular fibres features the capabilities to register the tensions of the zonular fork and lens capsule. The close location and neural connection towards the circular ciliary muscle portion could provide the basis for stabilization and readjustment of focusing that serves fast and fine\u2010tuned accommodation and disaccommodation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12257","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T20:12:48Z","timestamp":1445458368000},"page":"13-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Anteriorly located zonular fibres as a tool for fine regulation in accommodation"],"prefix":"10.1007","volume":"36","author":[{"given":"Cassandra M.","family":"Fl\u00fcgel\u2010Koch","sequence":"first","affiliation":[{"name":"Institute of Anatomy II Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Croft","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences University of Wisconsin\u2010Madison Madison Wisconsin USA"},{"name":"Wisconsin National Primate Research Center University of Wisconsin Madison USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"L\u00fctjen\u2010Drecoll","sequence":"additional","affiliation":[{"name":"Institute of Anatomy II Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,21]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"133","article-title":"Scanning electron microscopic studies of the zonular apparatus in human and monkey eyes","volume":"18","author":"Rohen JW","year":"1979","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3783"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(77)90135-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050245"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-0126-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(87)80153-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(87)80014-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)00502-3"},{"key":"e_1_2_7_11_1","first-page":"23","article-title":"Age\u2010dependent loss of accommodative amplitude in rhesus monkeys: an animal model for presbyopia","volume":"23","author":"Bito LZ","year":"1982","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1987.41"},{"issue":"6","key":"e_1_2_7_13_1","first-page":"R1885","article-title":"Accommodation dynamics in aging rhesus monkeys","volume":"275","author":"Croft MA","year":"1998","journal-title":"Am J Physiol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10846"},{"key":"e_1_2_7_15_1","first-page":"414","article-title":"Nerve cells in the human ciliary muscle: ultrastructural and immunocytochemical characterization","volume":"36","author":"Tamm ER","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070030075032"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00428041"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427855"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23100"}],"container-title":["Ophthalmic and Physiological Optics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fopo.12257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fopo.12257","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/opo.12257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:24:15Z","timestamp":1767785055000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/opo.12257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,21]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/opo.12257"],"URL":"https:\/\/doi.org\/10.1111\/opo.12257","archive":["Portico"],"relation":{},"ISSN":["0275-5408","1475-1313"],"issn-type":[{"value":"0275-5408","type":"print"},{"value":"1475-1313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,21]]},"assertion":[{"value":"2015-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}