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Capillary diameter and microaneurysm area changes were measured on the\n                      <jats:styled-content style=\"fixed-case\">AOSLO<\/jats:styled-content>\n                      structural maps. Imaging repeatability was established using longitudinal imaging of microvasculature in the healthy control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Capillary occlusion and recanalisation, capillary dilatation, resolution of local retinal haemorrhage, capillary hairpin formation, capillary bend formation, microaneurysm formation, progression and regression were documented over time in a region 2\u00b0 superior to the fovea in the\n                      <jats:styled-content style=\"fixed-case\">PDR<\/jats:styled-content>\n                      patient. An identical microvascular network with same capillary diameter was observed in the control subject over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      High\u2010resolution serial\n                      <jats:styled-content style=\"fixed-case\">AOSLO<\/jats:styled-content>\n                      imaging enables\n                      <jats:italic>in vivo<\/jats:italic>\n                      observation of vasculopathic changes seen in diabetes mellitus. The implications of this methodology are significant, providing the opportunity for studying the dynamics of the pathological process, as well as the possibility of identifying highly sensitive and non\u2010invasive biomarkers of end organ damage and response to treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12273","type":"journal-article","created":{"date-parts":[[2016,1,24]],"date-time":"2016-01-24T18:49:07Z","timestamp":1453661347000},"page":"290-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Longitudinal imaging of microvascular remodelling in proliferative diabetic retinopathy using adaptive optics scanning light ophthalmoscopy"],"prefix":"10.1007","volume":"36","author":[{"given":"Toco Yuen Ping","family":"Chui","sequence":"first","affiliation":[{"name":"Department of Ophthalmology New York Eye and Ear Infirmary of Mount Sinai New York NY 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