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Subjects were fitted with two different\n                      <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\n                      types, conventional hydrogel (Omafilcon A) and silicone hydrogel (comfilcon A), and exposed to two controlled indoor environmental conditions, standard [50% relative humidity (\n                      <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\n                      ), 23\u00b0C, 930\u00a0mb of atmospheric pressure] and adverse (in\u2010flight air cabin environment: 5%\n                      <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\n                      , localised air flow, 23\u00b0C, 750\u00a0mb atmospheric pressure), for 90\u00a0min in an environmental chamber, making a total of four visits. Symptoms, tear osmolarity, pre\u2010lens tear breakup time (\n                      <jats:styled-content style=\"fixed-case\">PLBUT<\/jats:styled-content>\n                      ), phenol red thread test, visual acuity, bulbar and limbal hyperaemia, corneal and limbal staining, and\n                      <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\n                      dehydration were assessed using repeated measures analysis of variance. A linear mixed model was used to analyse the effect of environment,\n                      <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\n                      type, discomfort\u2010based grouping, and time on blink rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Environment was found to significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a00.018) affect limbal and bulbar hyperaemia,\n                      <jats:styled-content style=\"fixed-case\">PLBUT<\/jats:styled-content>\n                      , tear osmolarity, and\n                      <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\n                      dehydration. Likewise,\n                      <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\n                      type significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a00.04) affected nasal and total corneal staining, limbal conjunctival staining,\n                      <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\n                      dehydration, comfort, and blurred vision. The environment,\n                      <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\n                      type, and time had significant effects (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a00.0001) on the blink rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Ocular surface integrity and blink rate in\n                      <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\n                      wearers depend on the environment\n                      <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\n                      users are exposed to, as well as on the soft\n                      <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\n                      type that they are wearing. Tight control of environmental conditions can contribute to a better understanding of\n                      <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\n                      \u2010related discomfort.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12338","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T19:05:31Z","timestamp":1482951931000},"page":"60-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Ocular response to environmental variations in contact lens wearers"],"prefix":"10.1007","volume":"37","author":[{"given":"Alberto","family":"L\u00f3pez\u2010de la Rosa","sequence":"first","affiliation":[{"name":"Ocular Surface Group IOBA University of Valladolid Valladolid 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