{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:56:23Z","timestamp":1791417383198,"version":"4.3.3"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Eye Institute, National Institutes of Health","award":["R01EY030193-01"],"award-info":[{"award-number":["R01EY030193-01"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Ocular diurnal rhythms have been implicated in myopia, glaucoma, diabetes, and other ocular pathologies. Ocular rhythms have been well described in adults; however, they have not yet been fully examined in children. The goal of this study was to investigate ocular and systemic diurnal rhythms over 24\u00a0h in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Subjects, ages 5 to 14\u00a0years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a018), wore a light, sleep, and activity monitor for one week to assess habitual sleep\/wake patterns, then underwent diurnal measurements every 4\u00a0h for 24\u00a0h. Measurements included blood pressure, heart rate, body temperature, intraocular pressure (\n                      <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\n                      ), ocular biometry, and optical coherence tomography imaging. Saliva was collected for melatonin and cortisol analysis. Mean ocular perfusion pressure was calculated from\n                      <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\n                      and blood pressure. Central corneal thickness, corneal power, anterior chamber depth, lens thickness, vitreous chamber depth, and axial length were determined from biometry. Total retinal thickness, retinal pigment epithelium (\n                      <jats:styled-content style=\"fixed-case\">RPE<\/jats:styled-content>\n                      ) + photoreceptor outer segment thickness, photoreceptor inner segment thickness, and choroidal thickness were determined for a 1\u00a0mm diameter centred on the fovea. Subjects\u2019 amplitude and acrophase of diurnal variation for each parameter were determined using Fourier analysis, and mean acrophase was calculated using unit vector averaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Repeated measures analysis of variance (\n                      <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>\n                      ) showed that all parameters except anterior chamber depth exhibited significant variations over 24\u00a0h (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      \u2264\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.005 for all). Axial length underwent diurnal variation of 45.25\u00a0\u00b1\u00a06.30\u00a0\u03bcm with an acrophase at 12.92\u00a0h, and choroidal thickness underwent diurnal variation of 26.25\u00a0\u00b1\u00a02.67\u00a0\u03bcm with an acrophase at 1.90\u00a0h.\n                      <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\n                      was approximately in phase with axial length, with a diurnal variation of 4.19\u00a0\u00b1\u00a00.50\u00a0mmHg and acrophase at 11.37\u00a0h. Total retinal thickness underwent a significant diurnal variation of 4.09\u00a0\u00b1\u00a00.39\u00a0\u03bcm with an acrophase at 15.04\u00a0h. The\n                      <jats:styled-content style=\"fixed-case\">RPE<\/jats:styled-content>\n                      + outer segment layer was thickest at 3.25\u00a0h, while the inner segment layer was thickest at 14.95\u00a0h. Melatonin peaked during the dark period at 2.36\u00a0h, and cortisol peaked after light onset at 9.22\u00a0h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Ocular and systemic diurnal rhythms were robust in children and similar to those previously reported in adult populations. Axial length and\n                      <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\n                      were approximately in phase with each other, and in antiphase to choroidal thickness. These findings may have important implications in myopia development in children.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12633","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T01:25:11Z","timestamp":1563845111000},"page":"358-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Twenty\u2010four hour ocular and systemic diurnal rhythms in children"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8675-1478","authenticated-orcid":false,"given":"Lisa A.","family":"Ostrin","sequence":"first","affiliation":[{"name":"College of Optometry University of Houston Houston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Jnawali","sequence":"additional","affiliation":[{"name":"College of Optometry University of Houston Houston 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