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This study aimed to investigate functional abnormalities using a frequency\u2010specific neuroimaging method in patients with concomitant exotropia (XT), and to demonstrate the clinical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Resting\u2010state functional magnetic resonance imaging data were collected in 26 XT patients and 26 matched controls. To evaluate the local spontaneous neural activity, the amplitude of low frequency fluctuations (ALFF) was calculated in the typical frequency band (0.01\u20130.08\u00a0Hz) as well as five narrowly\u2010defined frequency bands (slow\u20106: 0\u20130.01\u00a0Hz, slow\u20105: 0.01\u20130.027\u00a0Hz, slow\u20104: 0.027\u20130.073\u00a0Hz, slow\u20103: 0.073\u20130.167\u00a0Hz, and slow\u20102: 0.167\u20130.25\u00a0Hz), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with XT showed decreased ALFF in the bilateral parieto\u2010occipital sulcus (POS), and increased ALFF in the bilateral thalamus within the typical frequency band. Frequency\u2010dependent ALFF alterations were found in the higher visual areas such as the right lateral occipital complex (LOC). Furthermore, ALFF in the right LOC in the slow\u20105 band was positively correlated with fusion control score (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.70,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) and binocular function score (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.67,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0002). Regression analyses showed that early age of onset remained the only significant explanatory factor for ALFF reduction in the right POS in the typically\u2010measured frequency band (also referred to as the typical frequency band) (Odds ratio, 0.038; 95% confidence interval, 0.001 to 0.075).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings provide spatial information regarding the functionally disrupted regions in XT. Moreover, the frequency\u2010dependent ALLF alteration in the right LOC might reflect a potential plastic capacity in binocular function, which could be a potential objective index for evaluating disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12715","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T09:54:16Z","timestamp":1594893256000},"page":"650-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Disrupted neural signals in patients with concomitant exotropia"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-2967","authenticated-orcid":false,"given":"Sida","family":"Xi","sequence":"first","affiliation":[{"name":"Eye Research Institute and Department of Ophthalmology Eye &amp; ENT Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"Key Laboratory of Myopia Ministry of Health Fudan University Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration Fudan University Shanghai China"},{"name":"State Key Laboratory of Medical Neurobiology Institutes of Brain Science Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yao","sequence":"additional","affiliation":[{"name":"Eye Research Institute and Department of Ophthalmology Eye &amp; ENT Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"Key Laboratory of Myopia Ministry of Health Fudan University Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration Fudan University Shanghai China"},{"name":"State Key Laboratory of Medical Neurobiology Institutes of Brain Science Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eye Research Institute and Department of Ophthalmology Eye &amp; ENT Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"Key Laboratory of Myopia Ministry of Health Fudan University Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration Fudan University Shanghai China"},{"name":"State Key Laboratory of Medical Neurobiology Institutes of Brain Science Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Eye Research Institute and Department of Ophthalmology Eye &amp; ENT Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"Key Laboratory of Myopia Ministry of Health Fudan University Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration Fudan University Shanghai China"},{"name":"State Key Laboratory of Medical Neurobiology Institutes of Brain Science Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianqun","family":"Wu","sequence":"additional","affiliation":[{"name":"Eye Research Institute and Department of Ophthalmology Eye &amp; ENT Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"Key Laboratory of Myopia Ministry of Health Fudan University Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration Fudan University Shanghai China"},{"name":"State Key Laboratory of Medical Neurobiology Institutes of Brain Science Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinpei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Radiology Eye &amp; ENT Hospital Shanghai Medical College Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Brain and 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