{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T01:46:21Z","timestamp":1773452781141,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313793"],"award-info":[{"award-number":["2017A030313793"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515010077"],"award-info":[{"award-number":["2019A1515010077"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the inhibitory effect of bendazol on form\u2010deprivation myopia (FDM) in rabbits as well as the underlying biochemical processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010eight 3\u2010week\u2010old New Zealand white rabbits were randomly assigned to three groups: a control group, a form\u2010deprivation (FD) group and an FD\u00a0+\u00a0bendazol group (treated with 1% bendazol in the FD eyes). Refraction, corneal curvature, vitreous chamber depth (VCD) and axial length (AL) were assessed using streak retinoscopy, keratometry, and A\u2010scan ultrasonography, respectively. Eyeballs were enucleated for histological analysis, and ocular tissues were homogenized to determine the mRNA and protein expression of hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1) and muscarinic acetylcholine receptors (mAChRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bendazol inhibited the progression of FDM and suppressed the upregulation of HIF\u20101\u03b1. At week 6, in the control, FD and FD\u00a0+\u00a0bendazol groups, the refraction values were 1.38\u00a0\u00b1\u00a00.43, 0.03\u00a0\u00b1\u00a00.47 and 1.25\u00a0\u00b1\u00a00.35 D, respectively (\n                      <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                      0.001); the ALs were 13.91\u00a0\u00b1\u00a00.11, 14.15\u00a0\u00b1\u00a00.06 and 13.97\u00a0\u00b1\u00a00.10\u00a0mm, respectively (\n                      <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                      0.001) and the VCDs were 6.56\u00a0\u00b1\u00a00.06, 6.69\u00a0\u00b1\u00a00.07 and 6.61\u00a0\u00b1\u00a00.06\u00a0mm, respectively (\n                      <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                      0.001). HIF\u20101\u03b1 was upregulated in FD eyes but downregulated in FD\u00a0+\u00a0bendazol eyes, while the mAChRs were the opposite.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the FD rabbit model, bendazol significantly inhibits the development of myopia and downregulates HIF\u20101\u03b1 expression, which may provide a novel therapeutic approach for myopia control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12717","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T06:52:06Z","timestamp":1598338326000},"page":"567-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Topical bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF\u20101\u03b1 protein in young rabbits"],"prefix":"10.1007","volume":"40","author":[{"given":"Liyang","family":"Tong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7883-7677","authenticated-orcid":false,"given":"Junwen","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2010.01592.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.259"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.01.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.08.010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/519276a"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12305"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e31824ccbc3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001272"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000367"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.495"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2011.00884.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60272-4"},{"key":"e_1_2_7_14_1","first-page":"952","article-title":"Myopia. The nature versus nurture debate goes on","volume":"37","author":"Mutti DO","year":"1996","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2003.00145.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.9.4304"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.12.5510"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.4.1474"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.10.030187.001211"},{"key":"e_1_2_7_20_1","first-page":"279","article-title":"International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors","volume":"50","author":"Caulfield MP","year":"1998","journal-title":"Pharmacol Rev"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02733.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(97)00085-5"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.16.615"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0731-7085(87)80038-9"},{"key":"e_1_2_7_25_1","first-page":"860","article-title":"The application of bendazol in the prevention of cerebral ischemia","volume":"17","author":"Wang WH","year":"2010","journal-title":"J Pract Med Tech"},{"key":"e_1_2_7_26_1","first-page":"83","article-title":"Clinical study of bendazol combined with sibelium in the treatment of angioneurogenic headache","volume":"6","year":"2012","journal-title":"China J Pharmaceut Econ"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-017-3615-3"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-016-0002-7"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721443115"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.008"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.03.005"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20031155"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/750637"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.01.029"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.02.001"},{"key":"e_1_2_7_36_1","first-page":"138","article-title":"Chondrogenesis in scleral stem\/progenitor cells and its association with form\u2010deprived myopia in mice","volume":"21","author":"Wu PC","year":"2015","journal-title":"Mol Vis"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150909095403"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12054"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.38"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01506-5"},{"key":"e_1_2_7_41_1","first-page":"1234","article-title":"Changes in muscarinic acetylcholine receptor expression in form deprivation myopia in guinea pigs","volume":"13","author":"Liu Q","year":"2007","journal-title":"Mol Vis"},{"key":"e_1_2_7_42_1","first-page":"464","article-title":"Expression of muscarinic receptor subtypes in tree shrew ocular tissues and their regulation during the development of myopia","volume":"15","author":"McBrien NA","year":"2009","journal-title":"Mol Vis"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(02)00309-7"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2007.06.010"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-7088"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570164610666140109002531"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.12.061"}],"container-title":["Ophthalmic and Physiological Optics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/opo.12717","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/opo.12717","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/opo.12717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:25:30Z","timestamp":1767785130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/opo.12717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,24]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/opo.12717"],"URL":"https:\/\/doi.org\/10.1111\/opo.12717","archive":["Portico"],"relation":{},"ISSN":["0275-5408","1475-1313"],"issn-type":[{"value":"0275-5408","type":"print"},{"value":"1475-1313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,24]]},"assertion":[{"value":"2020-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}