{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:05:17Z","timestamp":1790010317734,"version":"4.0.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Hong Kong Polytechnic University"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report the 1\u2010year results of an investigation into whether there is an additive effect between 0.01% atropine and orthokeratology (ortho\u2010k), in a single\u2010masked, two\u2010arm, randomised controlled trial: Combined Atropine with Orthokeratology (AOK) for myopia control study (ClinicalTrials.gov number: NCT02955927).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Chinese children aged between 6 and 11\u00a0years with 1.00\u20134.00 D of myopia, astigmatism &lt;2.50 D, and no more than 1.00 D anisometropia, were randomly assigned either to an AOK group or ortho\u2010k only (OK) group at a 1:1 ratio. Subjects in the AOK group instilled one drop of 0.01% atropine into each eye, 10\u00a0min before nightly wear of ortho\u2010k lenses. The primary outcome, axial elongation, was examined at 6\u2010monthly intervals, along with secondary outcomes including best\u2010corrected visual acuity (BCVA), manifest refraction, accommodation, pupil size, and corneal topography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      29 AOK and 30 OK subjects completed the 1\u2010year visit. The overall axial elongation rate was significantly slower in the AOK group than in the OK group (mean (S.D.), 0.07 (0.16) mm vs 0.16 (0.15) mm, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0= 0.03). A significant between\u2010group difference in axial elongation was observed over the first 6\u2010month period only (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), but not over the second period (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.818). At the 1\u2010year visit, increases in mean (S.D.) mesopic and photopic pupil sizes in the AOK group were 0.64 (0.48) mm and 0.36 (0.34) mm, respectively, which were significantly higher than 0.10 (0.50) mm and 0.02 (0.28) mm in the OK group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). At the 6\u2010month visit, a significant moderate negative correlation was found between axial elongation and the increase in photopic pupil size (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.42,\u00a0\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      = 0.02) in the AOK group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is an additive effect between 0.01% atropine and ortho\u2010k over one year, with mean axial elongation in the AOK group 0.09\u00a0mm slower than that in the OK group. It appears that the additive effect was only during the first six months; a second\u2010year investigation is warranted to determine whether the effect is sustained over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12722","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T16:22:18Z","timestamp":1597076538000},"page":"557-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["One\u2010year results of 0.01% atropine with orthokeratology (AOK) study: a randomised clinical trial"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2694-3125","authenticated-orcid":false,"given":"Qi","family":"Tan","sequence":"first","affiliation":[{"name":"School of Optometry The Hong Kong Polytechnic University Kowloon Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex 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