{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:17:40Z","timestamp":1791227860309,"version":"4.1.0"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["990637"],"award-info":[{"award-number":["990637"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To study regional variations in choroidal thickness (CT), luminal thickness and stromal thickness of the choroid, and choroidal vascularity index (CVI) in low myopic and emmetropic eyes using wide\u2010field optical coherence tomography (OCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010nine healthy young adults between 20 and 38\u00a0years of age participated in this study, including 40\u00a0low myopes (mean \u00b1 SD spherical equivalent (MSE) refractive error: \u22123.00\u00a0\u00b1\u00a01.39 D, range: \u22126.00 to \u22120.62 D) and 29 emmetropes (MSE: \u22120.05\u00a0\u00b1\u00a00.09 D, range: \u22120.25 to +0.12 D). Wide\u2010field CT, luminal thickness, stromal thickness and CVI were measured across five eccentricities (fovea, parafovea, perifovea; near\u2010periphery and periphery) and four quadrants (nasal, temporal, inferior and superior), in vertical and horizontal meridians, while controlling for a range of extraneous factors potentially influencing the CT. Custom\u2010written software was used to segment and binarize the OCT images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Wide\u2010field CT, luminal thickness and stromal thickness, averaged across all participants, exhibited significant topographical variation, with the foveal (379\u00a0\u00b1\u00a08\u00a0\u00b5m, 200\u00a0\u00b1\u00a04\u00a0\u00b5m, 179\u00a0\u00b1\u00a04\u00a0\u00b5m, respectively) and peripheral (275\u00a0\u00b1\u00a08\u00a0\u00b5m, 161\u00a0\u00b1\u00a04\u00a0\u00b5m, 114\u00a0\u00b1\u00a04\u00a0\u00b5m, respectively) regions presenting the thickest and thinnest regions (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Wide\u2010field CVI showed a progressively higher percentage (greater vascularity) with increasing eccentricity from the fovea towards the periphery (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Macular CT and stromal choroidal thickness were significantly thinner in myopes compared to emmetropes (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Myopes (55.7\u00a0\u00b1\u00a00.3%) showed a slightly higher CVI compared with emmetropes (54.4\u00a0\u00b1\u00a00.4%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low myopia in young adults was associated with significant choroidal thinning across the macular, but not extramacular regions, with this decrease in choroidal thickness mostly attributed to thinning in the stromal component of the choroid, rather than the luminal (vascular) component.<\/jats:p>\n                  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