{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:48:25Z","timestamp":1768585705933,"version":"3.49.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["DPI2017\u201084047\u2010R"],"award-info":[{"award-number":["DPI2017\u201084047\u2010R"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29\u2010year\u2010old subject was designed. Once the proposed numerical model was validated, the decrease in accommodative amplitude with age was simulated according to data available in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In contrast with previous studies, the non\u2010accommodated eye condition was the reference configuration. Consequently, two aspects were specifically highlighted: contraction of the ciliary muscle, which was simulated by a continuum electro\u2010mechanical model and incorporation of initial lens capsule stresses, which allowed the lens to become accommodated after releasing the resting zonular tension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The morphological changes and contraction of the ciliary muscle were calibrated accurately according to the experimental data from the literature. All dynamic optical and biometric lens measurements validated the model. With the proposed numerical model, presbyopia was successfully simulated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The most widespread theory of accommodation, proposed by Helmholtz, was simulated accurately. Assuming the same initial stresses in the lens capsule over time, stiffening of the lens nucleus is the main cause of presbyopia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12876","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T04:21:04Z","timestamp":1630383664000},"page":"1241-1253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A validated finite element model to reproduce Helmholtz\u2019s theory of accommodation: a powerful tool to investigate presbyopia"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-2365","authenticated-orcid":false,"given":"Iulen","family":"Cabeza\u2010Gil","sequence":"first","affiliation":[{"name":"Arag\u03ccn Institute of Engineering Research (i3A) University of Zaragoza Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Grasa","sequence":"additional","affiliation":[{"name":"Arag\u03ccn Institute of Engineering Research (i3A) University of Zaragoza Zaragoza Spain"},{"name":"Bioengineering, Biomaterials and Nanomedicine Networking Biomedical Research Centre (CIBER\u2010BBN) Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Calvo","sequence":"additional","affiliation":[{"name":"Arag\u03ccn Institute of Engineering Research (i3A) University of Zaragoza Zaragoza Spain"},{"name":"Bioengineering, Biomaterials and Nanomedicine Networking Biomedical Research Centre (CIBER\u2010BBN) Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02720789"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1088\/1475-4878\/26\/5\/301"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)00502-3"},{"key":"e_1_2_9_5_1","volume-title":"Adler\u2019s Physiology of the Eye. 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