{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:14:50Z","timestamp":1790349290295,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the effect of varying the fluid reservoir (FR) thickness of scleral lenses (SL) on corrected distance visual acuity (CDVA), contrast sensitivity (CS) and higher\u2010order aberrations (HOAs) in keratoconic eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty eyes with keratoconus were fitted with a diagnostic Boston Sight SL having three different FR thicknesses. CDVA, CS and HOAs were measured before and after 30\u00a0min of lens wear. An i\u2010Trace aberrometer and anterior segment optical coherence tomography (AS\u2010OCT) were used to measure HOAs and FR thickness, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Statistically significant improvements in CDVA and CS were seen with different FR thickness lenses (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.01). Baseline CDVA (0.22\u00a0\u00b1\u00a00.15) improved to 0.03\u00a0\u00b1\u00a00.06, 0.04\u00a0\u00b1\u00a00.07 and 0.07\u00a0\u00b1\u00a00.08 with low, standard and high FR lenses, respectively.\n                      <jats:italic>Post<\/jats:italic>\n                      \u2010\n                      <jats:italic>hoc<\/jats:italic>\n                      testing showed better CDVA with low (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.006) and standard FR (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.009) lenses compared to high FR lenses. Before lens wear, CS was 1.27\u00a0\u00b1\u00a00.27, which improved to 1.67\u00a0\u00b1\u00a00.11, 1.73\u00a0\u00b1\u00a00.12 and 1.66\u00a0\u00b1\u00a00.89 with low, standard and high FR lenses, respectively. Lenses with standard FR showed better CS compared with those having low (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.009) and high FRs (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001). A statistically significant reduction of higher order\u2010root mean square aberrations (HO\u2010RMS), coma, spherical aberration, secondary astigmatism and trefoil were found with all FR thickness lenses compared to baseline (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.01). No significant difference was noted between lenses (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.01). All three lenses corrected almost equal amount of HOAs. A moderate positive correlation was observed between CDVA and HO\u2010RMS (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.61,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001) for low FR lenses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BostonSight SCLERALs were found to be very effective in improving vision, CS and reducing HOAs in keratoconus. Lenses with varying FR thickness showed equal effectiveness in visual performance and reducing HOAs. FR thickness should be considered an important factor to provide better vision and CS by minimising HOAs, as well as to maintain the normal physiology of eyes with keratoconus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12908","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T03:45:31Z","timestamp":1635133531000},"page":"178-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fluid reservoir thickness and aberration relationship in keratoconic eyes with scleral lenses"],"prefix":"10.1007","volume":"42","author":[{"given":"Akshaya C","family":"Balakrishnan","sequence":"first","affiliation":[{"name":"Elite School of Optometry Unit of Medical Research Foundation Sankara Nethralaya Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Badrinarayanan","sequence":"additional","affiliation":[{"name":"Department of Contact Lens Unit of Medical Research Foundation Sankara Nethralaya Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viswanathan","family":"Sivaraman","sequence":"additional","affiliation":[{"name":"Department of Optometry Contact Lens and Optical Services Elite School of Optometry Unit of Medical Research Foundation Sankara Nethralaya Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramar Mahesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Contact Lens Unit of Medical Research Foundation Sankara Nethralaya Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-1248","authenticated-orcid":false,"given":"Asif","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Contact Lens Unit of Medical Research Foundation Sankara Nethralaya Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182a73802"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2016.06.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2010.11.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.19.000620"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.01.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2019.06.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5935\/0004-2749.20180089"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000340"},{"key":"e_1_2_9_10_1","first-page":"36","article-title":"Scleral lenses: the benefits of toric landing zones","volume":"32","author":"Barnett M","year":"2017","journal-title":"CL Spectrum"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2017.07.002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e3182657da5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.10.027"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optom.2013.04.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2019.05.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e318288d19c"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000275"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000427"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2012.07.004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14038"},{"key":"e_1_2_9_21_1","unstructured":"HackerM FinchCE. Effect of scleral lens vault on best potential visual acuity contrast sensitivity and higher order aberrations (Doctoral dissertation). 2018."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2018.10.020"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.22374\/jclrs.v5i1.40"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000013"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2007.03.001"},{"key":"e_1_2_9_26_1","unstructured":"LotoczkyJ RosenJ NormanC.Scleral lens fit scales. Ferris State University Michigan College of Optometry.2014. Available at\u00a0ferris.edu\/HTMLS\/colleges\/michopt\/vision\u2010research\u2010institute\/pdfs\u2010docs\/Scleral\u2010lens\u2010fit\u2010scales_v2.pdf."},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-20071101-17"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.04.017"},{"key":"e_1_2_9_29_1","first-page":"951","article-title":"Total, corneal, and internal ocular optical aberrations in patients with keratoconus","volume":"25","author":"Schlegel Z","year":"2009","journal-title":"J Cataract Refract Surg"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2011.08.041"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5188"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702902"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.027029"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01279-4"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12802"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2020.03.009"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001560"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0141-7037(91)80057-S"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2014.09.008"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2006.09.001"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000988"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12814"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001558"}],"container-title":["Ophthalmic and Physiological Optics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/opo.12908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/opo.12908","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/opo.12908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:26:27Z","timestamp":1767785187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/opo.12908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,25]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/opo.12908"],"URL":"https:\/\/doi.org\/10.1111\/opo.12908","archive":["Portico"],"relation":{},"ISSN":["0275-5408","1475-1313"],"issn-type":[{"value":"0275-5408","type":"print"},{"value":"1475-1313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,25]]},"assertion":[{"value":"2021-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}