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However, systematic evaluation of existing clinical functional tests is lacking. This systematic review examines evidence for using clinical automated perimetry in routine assessment of early\/iAMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent findings<\/jats:title>\n                    <jats:p>PubMed, Web of Science Core Collection, and Embase were searched from inception to October 2020 to answer, is there evidence of visual field defects in early\/iAMD, and if so, are early\/iAMD visual field defects linked to real\u2010world patient outcomes? Articles using clinical automated perimetry (commercially accessible and non\u2010modified devices\/protocols) were included. Microperimetry was excluded as this has yet to be incorporated into clinical guidelines. The primary outcome was global visual field indices including mean deviation (MD), pattern standard deviation (PSD), mean sensitivity (MS) and frequency of defects. The secondary outcome was any real\u2010world patient outcome including quality of life and\/or activities of daily living indices. Twenty\u2010six studies were eligible for inclusion and all studies were observational. There was consistent evidence of worsened MD, PSD, MS and frequency of defects for early\/iAMD compared to normal eyes under photopic, low\u2010photopic and scotopic conditions. Meta\u2010analysis of studies using standard automated perimetry (SAP) under photopic conditions revealed worsened MD (\u22121.52dB [\u22122.27, \u22120.78\u00a0dB]) and MS (\u22121.47dB [\u22122, \u22120.94\u00a0dB]) in early\/iAMD compared to normal eyes, representing large statistical effect sizes but non\u2010clinically meaningful reductions. There was insufficient data for meta\u2010analyses regarding other clinical automated perimetry protocols. Only one study assessed a real\u2010world patient outcome (on\u2010road driving performance), with no significant link to visual field outcomes in early\/iAMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Significant reduction of global visual field indices is present in early\/iAMD, but not clinically meaningful using SAP under photopic conditions. Translational relevance of visual field outcomes to patient outcomes in early\/iAMD remains unclear. Thus, SAP under photopic conditions is unlikely to be useful for routine assessment of early\/iAMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12919","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T10:42:16Z","timestamp":1638182536000},"page":"161-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Should clinical automated perimetry be considered for routine functional assessment of early\/intermediate age\u2010related macular degeneration (AMD)? 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