{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:30Z","timestamp":1787015970763,"version":"build-2736575974"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the effect of low\u2010intensity, long\u2010wavelength red light therapy (LLRT) on the inhibition of myopia progression in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted. One hundred and five myopic children (spherical equivalent refractive error [SER] \u22123.09\u00a0\u00b1\u00a01.74 dioptres [D]; mean age, 9.19\u00a0\u00b1\u00a02.40\u00a0years) who underwent LLRT treatment (power 0.4\u00a0mW, wavelength 635\u00a0nm) twice per day for 3\u00a0min each session, with at least a 4\u2010h interval between sessions, and a control group of 56\u00a0myopic children (SER \u22123.04\u00a0\u00b1\u00a01.66\u00a0D; mean age, 8.62\u00a0\u00b1\u00a02.45\u00a0years) were evaluated. Both groups wore single\u2010vision distance spectacles. Each child returned for a follow\u2010up examination every 3\u00a0months after the initial measurements for a total of 9\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 9\u00a0months, the mean SER in the LLRT group was \u22122.87\u00a0\u00b1\u00a01.89\u00a0D, significantly greater than that of the control group (\u22123.57\u00a0\u00b1\u00a01.49\u00a0D,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Axial length (AL) changes were \u22120.06\u00a0\u00b1\u00a00.19\u00a0mm and 0.26\u00a0\u00b1\u00a00.15\u00a0mm in the LLRT group and control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), respectively. The subfoveal choroidal thickness changed by 45.32\u00a0\u00b1\u00a030.88\u00a0\u03bcm for children treated with LLRT at the 9\u2010month examination (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Specifically, a substantial hyperopic shift (0.31\u00a0\u00b1\u00a00.24\u00a0D and 0.20\u00a0\u00b1\u00a00.14\u00a0D, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02) was found in the 8\u201314\u00a0year olds compared with 4\u20137\u00a0year old children. The decrease in AL in subjects with baseline AL &gt;24\u00a0mm was \u22120.08\u00a0\u00b1\u00a00.19\u00a0mm, significantly greater than those with a baseline AL \u226424\u00a0mm (\u22120.04\u00a0\u00b1\u00a00.18\u00a0mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Repetitive exposure to LLRT therapy was associated with slower myopia progression and reduced axial growth after short durations of treatment. These results require further validation in randomised controlled trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12939","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:39:37Z","timestamp":1641256777000},"page":"335-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Low\u2010intensity, long\u2010wavelength red light slows the progression of myopia in children: an Eastern China\u2010based cohort"],"prefix":"10.1007","volume":"42","author":[{"given":"Lei","family":"Zhou","sequence":"first","affiliation":[{"name":"Ningbo Eye Hospital Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yuying Children's Hospital The Second Affiliated Hospital of Wenzhou Medical University Wenzhou 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