{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:02:46Z","timestamp":1788631366241,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T00:00:00Z","timestamp":1648857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the treatment zone (TZ) measurements obtained using manual and software\u2010based methods in orthokeratology (ortho\u2010k) subjects and explore the TZ characteristics of children with slow and fast axial elongation after ortho\u2010k.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data from 69 subjects (aged 7 to &lt;13\u00a0years old), who participated in three 24\u2010month longitudinal orthokeratology studies, showing fast (&gt;0.27\u00a0mm,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a038) and slow (&lt;0.09\u00a0mm,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a031) axial elongation, were retrieved. The TZ after ortho\u2010k was defined as the central flattened area enclosed by points with no refractive power change. TZ parameters, including decentration, size, width of the peripheral steepened zone (PSZ), central and peripheral refractive power changes and peripheral rate of power change, were determined manually and using python\u2010based software. TZ parameters were compared between measurement methods and between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Almost all TZ parameters measured manually and with the aid of software were significantly different (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Differences in decentration, size and the PSZ width were not clinically significant, but differences (0.45 to 0.92 D) in refractive power change in the PSZ were significant, although intraclass coefficients (0.95 to 0.98) indicated excellent agreement between methods. Significantly greater TZ decentration, smaller TZ size and greater inferior rate of power change (relative to the TZ centre) were observed in slow progressors using both methods, suggesting a potential role of TZ in regulating myopia progression in ortho\u2010k.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TZ measurements using manual and software\u2010based methods differed significantly and cannot be used interchangeably. The combination of TZ decentration, TZ size and peripheral rate of power change may affect myopia control effect in ortho\u2010k.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12981","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T10:31:13Z","timestamp":1648895473000},"page":"773-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Manual and software\u2010based measurements of treatment zone parameters and characteristics in children with slow and fast axial elongation in orthokeratology"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-8143","authenticated-orcid":false,"given":"Biyue","family":"Guo","sequence":"first","affiliation":[{"name":"Centre for Myopia Research, School of Optometry The Hong Kong Polytechnic University  Hong Kong SAR 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