{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:48:44Z","timestamp":1780570124749,"version":"3.54.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T00:00:00Z","timestamp":1653177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate whether the treatment zone (TZ) decentration in orthokeratology (OK) lenses affects retinal expansion in Chinese children with myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Children aged 8 to 13\u2009years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030) were assessed over 13\u2009months comprising 12\u2009months of OK lens wear followed by discontinuation of lens wear for 1\u00a0month. Corneal topography was measured at 0, 1, 3, 6, 9, 12 and 13\u2009months. TZ decentration of the OK lens was calculated, and subjects were subdivided into a small decentration group (group S) and a large decentration group (group L) based on the median value of the weighted average decentration (d\n                      <jats:sub>ave<\/jats:sub>\n                      ). Central axial length (AL) and peripheral eye lengths (PELs) at the central retina, as well as 10\u00b0, 20\u00b0 and 30\u00b0 nasally and temporally were measured at 0 and 13\u2009months under cycloplegia. Second\u2010order polynomial (\n                      <jats:italic>y<\/jats:italic>\n                      \u00a0=\u00a0ax\n                      <jats:sup>2<\/jats:sup>\n                      \u2009+\u2009bx\u2009+\u2009c) and linear fits (\n                      <jats:italic>y<\/jats:italic>\n                      \u00a0=\u00a0Kx\u2009+\u2009B) were applied to the peripheral relative eye length (PREL), and the coefficients \u2018a\u2019 and \u2018K\u2019 were used to describe the shape of the eye.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean AL growth for one year was 0.28\u2009\u00b1\u20090.17\u2009mm. In a multiple linear regression model, AL elongation was related to the baseline age (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01) and the d\n                      <jats:sub>ave<\/jats:sub>\n                      (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03) (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002). When compared with smaller d\n                      <jats:sub>ave<\/jats:sub>\n                      (0.45\u2009\u00b1\u20090.15\u2009mm), a larger d\n                      <jats:sub>ave<\/jats:sub>\n                      (0.89\u2009\u00b1\u20090.17\u2009mm) was associated with slower ocular growth (central: 0.20\u2009\u00b1\u20090.13\u2009mm vs. 0.35\u2009\u00b1\u20090.17\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009; 10\u00b0 nasal: 0.26\u2009\u00b1\u20090.18\u2009mm vs. 0.45\u2009\u00b1\u20090.21\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02; 10\u00b0 temporal: 0.17\u2009\u00b1\u20090.14\u2009mm vs. 0.32\u2009\u00b1\u20090.19\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02) and more oblate retina shape (\u2018a\u2019: \u22120.13\u2009\u00b1\u20090.02 vs. \u22120.14\u2009\u00b1\u20090.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02; K\n                      <jats:sub>nasal<\/jats:sub>\n                      : 0.35\u2009\u00b1\u20090.11 vs. 0.39\u2009\u00b1\u20090.09,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02; K\n                      <jats:sub>temporal<\/jats:sub>\n                      : \u22120.42\u2009\u00b1\u20090.08 vs. \u22120.46\u2009\u00b1\u20090.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Greater TZ decentration with the use of OK lenses was associated with slower axial growth and a more oblate retinal shape. TZ decentration caused local defocusing changes, which may inhibit myopic progression. These findings may have important implications for improving optical designs for myopia control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.12996","type":"journal-article","created":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T07:32:48Z","timestamp":1653204768000},"page":"1124-1132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Treatment zone decentration promotes retinal reshaping in Chinese myopic children wearing orthokeratology lenses"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6326-9109","authenticated-orcid":false,"given":"Xue","family":"Li","sequence":"first","affiliation":[{"name":"Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical University  Wenzhou China"},{"name":"National Clinical Research Center for Ocular Diseases  Wenzhou 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