{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:09:51Z","timestamp":1773101391822,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY024542"],"award-info":[{"award-number":["R01EY024542"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Reflectance of retinal nerve fibre layer (RNFL) can contribute to detecting the presence of glaucomatous damage and defining its extent. As a step towards developing a normative database for RNFL reflectance, we assessed within\u2010eye and between\u2010subject variability for RNFL reflectance in healthy eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Vertical 30\u00b0\u2009\u00d7\u200915\u00b0 volume scans at the optic disc were gathered using SD\u2010OCT (Spectralis OCT) from people free of eye disease. Scans were gathered for both eyes of 30 younger adults (mean\u2009\u00b1\u2009SD\u00a0=\u00a027\u2009\u00b1\u20093\u2009years) and for one eye of 30 older adults (68\u2009\u00b1\u20098\u2009years). Reflectance was quantified for each voxel as the depth\u2010resolved attenuation coefficient (AC). Values for AC were extracted for four slabs (0\u201352, 24\u201352, 24\u201336 and 36\u201360\u2009\u03bcm) and at depths from 24 to 60\u2009\u03bcm below the inner limiting membrane (ILM) in 4\u00a0\u03bcm steps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between\u2010subject and within\u2010eye standard deviations (SDs) for the logarithm of AC were similar; median differences were 0.02\u20130.03 log unit across all four slabs and depths from 24 to 48\u2009\u03bcm. Means for the logarithm of AC were higher for younger than older eyes by ~0.1 log unit; this age effect was not due to differences in the raw reflectance of the RNFL, but rather to age\u2010related changes in reflectance of deeper retina affecting the calculation of AC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In both groups, within\u2010eye variability in RNFL reflectance near the optic disc was similar to between\u2010subject variability. A better understanding of within\u2010eye variability would be useful for developing normative databases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13027","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T02:24:46Z","timestamp":1659407086000},"page":"1316-1325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Within\u2010eye and between\u2010subject variability for reflectance of the retinal nerve fibre layer"],"prefix":"10.1007","volume":"42","author":[{"given":"Hin","family":"Cheung","sequence":"first","affiliation":[{"name":"Indiana University School of Optometry  Bloomington Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-3658","authenticated-orcid":false,"given":"William H.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Indiana University School of Optometry  Bloomington Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett J.","family":"King","sequence":"additional","affiliation":[{"name":"Indiana University School of Optometry  Bloomington Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15506"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-310642"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330305"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903000103"},{"key":"e_1_2_9_7_1","first-page":"2012","article-title":"Human optic nerve fiber count and optic disc size","volume":"33","author":"Jonas JB","year":"1992","journal-title":"Invest Ophthalmol Vis 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