{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:38:09Z","timestamp":1773481089246,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008436","name":"Ernst und Berta Grimmke Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Prematurity and retinopathy of prematurity (ROP) are associated with altered corneal shape and reduced visual acuity in childhood, but their long\u2010term effects on corneal shape in later life are still unclear. This study evaluated whether prematurity and related perinatal factors are associated with corneal aberrations in adulthood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Gutenberg Prematurity Eye Study (GPES) is a cohort study using Scheimpflug imaging of the cornea. Associations were assessed between corneal Zernike aberrations and gestational age (GA), birth weight (BW), BW percentile, ROP occurrence, ROP treatment and other perinatal factors using univariate and multivariable linear regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study involved 444 eyes of 256 individuals born preterm (aged 28.1\u00a0\u00b1\u00a08.4\u2009years, 146 females) and 231 eyes of 132 individuals born full\u2010term (aged 29.8\u00a0\u00b1\u00a08.9\u2009years, 77 females). Multivariable analyses revealed an association between corneal higher\u2010order aberrations and lower birth weight percentile (B\u00a0=\u00a0\u22120.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001) as well as ROP treatment (B\u00a0=\u00a00.120,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.03). Corneal lower\u2010order aberrations were also associated with lower birth weight percentile (B\u00a0=\u00a0\u22120.004;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.001) and ROP treatment (B\u00a0=\u00a00.838,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.01) but not with ROP occurrence. Increased corneal aberrations were correlated with lower visual acuity and the spherical equivalent refractive error.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Perinatal factors, particularly low birth weight percentile and ROP treatment lead to a more irregular corneal shape in adulthood, thereby reducing optical image quality and potentially contributing to reduced visual acuity and altered refractive error.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13038","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T12:13:53Z","timestamp":1661429633000},"page":"1379-1389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The role of preterm birth, retinopathy of prematurity and perinatal factors on corneal aberrations in adulthood: Results from the Gutenberg prematurity eye study"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3867-2350","authenticated-orcid":false,"given":"Achim","family":"Fie\u00df","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina Amalia","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana C.","family":"Riedl","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Mildenberger","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Urschitz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Epidemiology, Institute for Medical Biostatistics, Epidemiology and Informatics University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Hampel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Wasielica\u2010Poslednik","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Zepp","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Stoffelns","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander 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