{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T14:28:18Z","timestamp":1767796098006,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81790641"],"award-info":[{"award-number":["81790641"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0112700"],"award-info":[{"award-number":["2020YFA0112700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate activation of the lesion projection zone (LPZ) in the primary visual cortex during end\u2010stage glaucoma using functional magnetic resonance imaging (fMRI), as well as the relationship between fMRI responses and clinical data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve subjects with bilateral end\u2010stage glaucoma (group A), 12 with unilateral end\u2010stage glaucoma (group B) and 12 healthy controls (group C) were enrolled. fMRI was performed under two testing stimuli conditions: passive viewing of a full\u2010field flickering checkerboard and active viewing of a one\u2010back task with scene images. In fMRI analysis, the primary visual cortex was divided into six regions of interest (ROIs). The beta values of the six ROIs were compared across the three groups using one\u2010way analysis of variance under two viewing conditions. Associations between the fMRI beta value and clinical data including multifocal electroretinogram (mfERG), microperimeter\u20101 and optical coherence tomography were analysed by Spearman correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The beta values for ROIs 1\u20133 representing the LPZ were significantly different between the three groups under active viewing conditions, whereas no significant changes were detected under passive viewing. In group A, there were significant differences between all six ROIs for the two viewing conditions, while no significant differences were found in groups B and C. In group A, the P\u2010wave amplitudes of the mfERG was significantly correlated with the beta values of ROIs 1 and 2 under active viewing. In addition, the P\u2010wave latencies of the mfERG were significantly correlated with the beta values for ROIs 2\u20135. No associations were found between fMRI beta values and clinical data in groups B and C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Activation of the LPZ in the primary visual cortex was observed in patients with bilateral end\u2010stage glaucoma under active viewing conditions. These changes were correlated with residual retinal function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13044","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T11:29:05Z","timestamp":1661945345000},"page":"1159-1169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Activation of lesion projection zone in primary visual cortex is dependent on bilateral central vision loss in patients with end\u2010stage glaucoma"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4292-9507","authenticated-orcid":false,"given":"Wenqing","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology &amp; Visual Science, Eye &amp; ENT Hospital, Shanghai Medical College Fudan University  Shanghai 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