{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:58:33Z","timestamp":1790117913080,"version":"4.0.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The inter\u2010session repeatability (ISR), inter\u2010examiner reproducibility (IER) and within\u2010subject variability (WSV) of the Cobra HD fundus camera meibographer were examined in participants with and without dry eye symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Symptoms were determined based on Ocular Surface Disease Index scores (\u226513 being considered symptomatic), and subgroups were compared using the Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010test. Images of meibomian glands (MGs) from the upper and lower right eyelids were captured by two examiners on the same day (S1) to determine IER. One examiner repeated the measurements on a second day (S2) to obtain the ISR. ISR, IER and WSV were calculated using Friedman,\u00a0correlation tests and Bland and Altman analyses with mean differences (md) and 95% confidence intervals (CIs), within\u2010subject standard deviations (Sw) and intra\u2010class correlation coefficients (ICC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ISR experiment included 72 participants (mean age: 23\u2009\u00b1\u20095\u2009years, range: 19\u201343, 36 symptomatic). Mean MG loss of the upper (S1: 13.5\u2009\u00b1\u20099.5%, S2: 12.8\u2009\u00b1\u20098.5%) and lower eyelids (S1: 7.5\u2009\u00b1\u20096.9%, S2: 7.3\u2009\u00b1\u20096.3%) was not significantly different between sessions for all participants, symptomatic and asymptomatic subgroups for both eyelids. The ISR Sw for the upper and lower eyelids was 1.3% and 1.0%; md was 0.7\u2009\u00b1\u20093.5% (CI:\u22126.25% to 7.62%) and 0.1\u2009\u00b1\u20092.1% (CI: \u22123.94% to 4.17%), respectively. The IER experiment included 74 participants (mean age: 23\u2009\u00b1\u20095\u2009years, range: 19\u201343, 37 symptomatic). Mean MG loss of the upper (Examiner 1: 12.7\u2009\u00b1\u20098.2%, Examiner 2: 13.1\u2009\u00b1\u20098.0%) and lower eyelids (Examiner 1: 7.0\u2009\u00b1\u20096.2%, Examiner 2: 7.4\u2009\u00b1\u20096.2%) was not significantly different between examiners for all participants, symptomatic and asymptomatic subgroups for both eyelids. The IER ICC values were &gt;0.86 for all conditions, Sw was 1.3% and 1.2%, with a md of \u22120.4\u2009\u00b1\u20093.2% (CI: \u22126.65% to 5.90%) and \u22120.4\u2009\u00b1\u20092.9% (CI: \u22126.15% to 5.31%), respectively. The WSV Sw values were &lt;1.4%, and ICC values were &gt;0.89 for both eyelids, examiners and experimental sessions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The Cobra HD fundus camera demonstrates good repeatability, reproducibility and low WSV, and is a reliable clinical instrument for meibography.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13074","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T11:22:58Z","timestamp":1669807378000},"page":"183-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Repeatability and reproducibility of Cobra HD fundus camera meibography in young adults with and without symptoms of dry 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