{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T14:16:58Z","timestamp":1767795418902,"version":"3.49.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21EB028084"],"award-info":[{"award-number":["R21EB028084"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To develop a point\u2010of\u2010care (POC) device using high\u2010frequency ultrasound (US) for evaluating microstructural changes in the anterior sclera associated with myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The proposed POC device must satisfy four primary requirements for effective clinical use: the measurement component is handheld; the software must be simple and provide real\u2010time feedback; patient safety and health data security requirements set forth by relevant governing bodies must be satisfied and the measurement data must have sufficient signal\u2010to\u2010noise ratio (SNR) and repeatability. Radiofrequency (RF) echo data acquired by the POC device will be processed using our quantitative US methods to characterise tissue microstructure and biomechanical properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All stated requirements have been met in the developed POC device. The high\u2010frequency transducer is housed in a custom, 3D\u2010printed, pen\u2010like holder that allows for easy measurements of the anterior sclera. Custom software provides a simple interface for data acquisition, real\u2010time data display and secure data storage. Exposimetry measurements of the US pressure field indicate device compliance with United States Food and Drug Administration limits for ophthalmic US. In vivo measurements on a volunteer suggest the RF data SNR and acquisition consistency are suitable for quantitative analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A fully functioning POC device using high\u2010frequency US has been created for evaluating the microstructure of the anterior sclera. Planned studies using the POC device to scan the eyes of myopia patients will help clarify how the anterior sclera microstructure may be affected by myopia. If effective, this portable, inexpensive and user\u2010friendly system could be an important part of routine eye examinations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13122","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T10:41:19Z","timestamp":1679395279000},"page":"544-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High\u2010frequency ultrasound point\u2010of\u2010care device to quantify myopia\u2010induced microstructural changes in the anterior sclera"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-095X","authenticated-orcid":false,"given":"Cameron","family":"Hoerig","sequence":"first","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan V.","family":"Hoang","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Duke\u2010NUS  Singapore City Singapore"},{"name":"Department of Ophthalmology, Yong Loo Lin School of Medicine National University of Singapore  Singapore City Singapore"},{"name":"Department of Ophthalmology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Aichele","sequence":"additional","affiliation":[{"name":"Department of Earth Sciences Institute of Geophysics, Swiss Federal Institute of Technology  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Catheline","sequence":"additional","affiliation":[{"name":"Univ Lyon, Universit\u00e9 Lyon 1, Centre L\u00e9on B\u00e9rard, INSERM, LabTAU  Lyon 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