{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T02:41:34Z","timestamp":1780972894663,"version":"3.54.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011718","name":"Macular Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The relationship between perimetric stimulus area and Ricco's area (RA) determines measured thresholds and the sensitivity of perimetry to retinal disease. The nature of this relationship, in addition to effect of retinal ganglion cell (RGC) number on this, is currently unknown for the adaptation conditions of mesopic microperimetry. In this study, achromatic mesopic spatial summation was measured across the central visual field to estimate RA with the number of RGCs underlying RA also being established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Achromatic luminance thresholds were measured for six incremental spot stimuli (0.009\u20132.07\u2009deg\n                      <jats:sup>2<\/jats:sup>\n                      ) and 190.4\u2009ms duration, at four locations, each at 2.5\u00b0, 5\u00b0 and 10\u00b0 eccentricity in five healthy observers (mean age 61.4\u2009years) under mesopic conditions (background 1.58\u2009cd\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). RA was estimated using two\u2010phase regression analysis with the number of RGCs underlying RA being calculated using normative histological RGC counts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ricco's area exhibited a small but statistically insignificant increase between 2.5\u00b0 and 10\u00b0 eccentricity. Compared with photopic conditions, RA was larger, with the difference between RA and the Goldmann III stimulus (0.43\u00b0) being minimised. RGC number underlying RA was also higher than reported for photopic conditions (median 70 cells, IQR 36\u201393), with no significant difference being observed across test locations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ricco's area and the number of RGCs underlying RA do not vary significantly across the central visual field in mesopic conditions. However, RA is larger and more similar to the standard perimetric Goldmann III stimulus under mesopic compared with photopic adaptation conditions. Further work is required to determine if compensatory enlargements in RA occur in age\u2010related macular degeneration, to establish the optimal stimulus parameters for AMD\u2010specific microperimetry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13158","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T03:00:06Z","timestamp":1682737206000},"page":"1179-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigating the linkage between mesopic spatial summation and variations in retinal ganglion cell density across the central visual field"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0150-4126","authenticated-orcid":false,"given":"Aoife M. 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