{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T14:30:04Z","timestamp":1768919404123,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate the choroidal vascularity index (CVI) as an activity criterion in chronic central serous chorioretinopathy (CSC) and as a measure of treatment response after full\u2010dose\u2010full\u2010fluence photodynamic therapy (fd\u2010ff\u2010PDT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This fellow\u2010eye\u2010controlled, retrospective cohort study included 23 patients with unilateral chronic CSC treated with fd\u2010ff\u2010PDT (6\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; 50\u2009\u03bccm\n                      <jats:sup>2<\/jats:sup>\n                      ; 83\u2009s). Subfoveal choroidal thickness (SFCT, \u03bcm) and CVI (%) of the affected and fellow eyes at baseline as well as at 1, 3 and 6\u2009months after fd\u2010ff\u2010PDT were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patients' mean age was 43.4\u2009\u00b1\u20097.3\u2009years, and 18 (78.3%) were male. CVI was comparable between the affected and fellow eyes at baseline (66.09\u2009\u00b1\u20091.56 vs. 65.84\u2009\u00b1\u20091.57,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.59). However, it became significantly lower in the affected eyes 1 (64.45\u2009\u00b1\u20091.68 vs. 65.87\u2009\u00b1\u20091.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), 3 (64.21\u2009\u00b1\u20092.08 vs. 65.71\u2009\u00b1\u20091.59,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) and 6 (64.47\u2009\u00b1\u20092.19 vs. 65.62\u2009\u00b1\u20091.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) months after fd\u2010ff\u2010PDT. The mean SFCT and the mean CVI were significantly decreased in the affected eyes at all follow\u2010up visits compared with baseline after fd\u2010ff\u2010PDT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>At baseline, CVI was comparable between affected and fellow eyes. Therefore, its use as an activity criterion in chronic CSC patients is questionable. However, it was significantly decreased in fd\u2010ff\u2010PDT\u2010treated eyes, supporting its role as a measure of treatment response in chronic CSC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13187","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T06:38:46Z","timestamp":1686811126000},"page":"1203-1210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Choroidal vascularity index as an activity criterion and a treatment response measure in chronic central serous chorioretinopathy"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7130-4798","authenticated-orcid":false,"given":"Mehmet Orkun","family":"Sevik","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Marmara University School of Medicine  Istanbul 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