{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:25:35Z","timestamp":1776403535384,"version":"3.51.2"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the change in crystalline lens power (LP) in a cohort of Indian children with progressive myopia receiving atropine (0.01%) compared with an untreated control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Nonrandomised clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 120 children (70 in the atropine group; 50 in the control group) with progressive myopia (\u22650.5\u2009D\/year) with a 1\u2010year follow\u2010up. The atropine group received 0.01% atropine eye drops once daily in both eyes, whereas the control group received no treatment. Changes in cycloplegic spherical equivalent, axial length (AL), keratometry (KER), anterior chamber depth (ACD) and lens thickness (LT) were recorded. LP was calculated using the formula proposed by Bennett.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean myopia progression at year 1 was significantly less in the atropine group (\u22120.18\u2009D [0.2]) than in the control group (\u22120.59 [0.21];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The increase in AL was significantly different between the two groups (atropine: 0.21\u2009mm [0.12]; control: 0.29\u2009mm [0.11],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A significantly greater loss of LP was noted in the atropine group (\u22120.67\u2009D [0.34]) than in the placebo group (\u22120.28\u2009D [0.42];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The change in LT was significantly different between the atropine and control groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), whereas the change in ACD and KER was similar in the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The greater loss of LP could contribute to the anti\u2010myopia effect of atropine and should therefore be evaluated in studies reporting the efficacy of atropine on myopia to assess its actual effect on myopic progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13192","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T20:22:27Z","timestamp":1687638147000},"page":"1406-1411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of low\u2010dose atropine (0.01%) on crystalline lens power among school\u2010aged children with progressive myopia"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8660-8062","authenticated-orcid":false,"given":"Rohit","family":"Saxena","sequence":"first","affiliation":[{"name":"Paediatric Ophthalmology and Strabismus Services Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Gupta","sequence":"additional","affiliation":[{"name":"Paediatric Ophthalmology and Strabismus Services Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebika","family":"Dhiman","sequence":"additional","affiliation":[{"name":"Paediatric Ophthalmology and Strabismus Services Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Phuljhele","sequence":"additional","affiliation":[{"name":"Paediatric Ophthalmology and Strabismus Services Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Paediatric Ophthalmology and Strabismus Services Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namrata","family":"Sharma","sequence":"additional","affiliation":[{"name":"Paediatric Ophthalmology and Strabismus Services Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3719-2195","authenticated-orcid":false,"given":"Rafael","family":"Iribarren","sequence":"additional","affiliation":[{"name":"Drs Iribarren Eye Consultants  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos","family":"Rozema","sequence":"additional","affiliation":[{"name":"Visual Optics Lab Antwerp (VOLANTIS), Faculty of Medicine and Health Science University of Antwerp  Antwerp Belgium"},{"name":"Department of Ophthalmology Antwerp University Hospital  Edegem Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.031"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.12.011"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.05.032"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004916.pub3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.1091"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.01.026"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.06.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100923"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1985.01050060045020"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886\u2010021\u201002001\u20106"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.70.2.152"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.1988.tb01082.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7899"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-7108"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.02.002"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18047"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3431"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-3090"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3181b2f903"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.008"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2013.02.008"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14716"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12781"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25955"},{"key":"e_1_2_10_26_1","first-page":"1728","article-title":"Tropicamide (1%): an effective cycloplegic agent for myopic children","volume":"42","author":"Manny RE","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Ophthalmic and Physiological Optics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/opo.13192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:23:32Z","timestamp":1767785012000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/opo.13192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,23]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/opo.13192"],"URL":"https:\/\/doi.org\/10.1111\/opo.13192","archive":["Portico"],"relation":{},"ISSN":["0275-5408","1475-1313"],"issn-type":[{"value":"0275-5408","type":"print"},{"value":"1475-1313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,23]]},"assertion":[{"value":"2022-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}