{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:20:42Z","timestamp":1790032842908,"version":"4.0.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effect of repeated low\u2010level red\u2010light therapy (RLRLT) on retinal and choroidal blood perfusion in myopic children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010seven myopic children (mean spherical equivalent refractive error [SE]: \u22122.31\u2009\u00b1\u20091.26 D; age range: 8.0\u201311.0\u2009years) were enrolled and received RLRLT (power 2\u2009mW, wavelength 650\u2009nm) for 3\u2009min twice a day, while 20 myopic children (SE: \u22122.75\u2009\u00b1\u20090.84 D; age range: 7.0\u201310.0\u2009years) were included as a control group. All participants wore single\u2010vision distance glasses. Refractive error, axial length (AL) and other biometric parameters were measured at baseline and during follow\u2010up visits in the first, second and fourth weeks after initiation of treatment. Retinal thickness, subfoveal choroidal thickness (SFCT), total choroidal area (TCA), luminal area (LA), stromal area (SA) and choroidal vascularity index (CVI) were obtained using optical coherence tomography (OCT). The percentage retinal vascular density (VD%) and choriocapillaris flow voids (FV%) were measured using en\u2010face OCT angiography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 4\u2009weeks of treatment, a significant increase in SFCT was observed in the RLRLT group, with an average increase of 14.5\u2009\u03bcm (95% confidence interval [CI]: 9.6\u201319.5\u2009\u03bcm), compared with a decrease of \u22121.7\u2009\u03bcm (95% CI: \u22129.1 to 5.7\u2009\u03bcm) in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). However, no significant changes in retinal thickness or VD% were observed in either group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). In the OCT images from the RLRLT group, no abnormal retinal morphology related to photodamage was observed. The\u00a0horizontal scans revealed an increase in TCA, LA and CVI over time (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while SA and FV% remained unchanged (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that RLRLT can enhance choroidal blood perfusion in myopic children, demonstrating a cumulative effect over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13202","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T02:16:05Z","timestamp":1689041765000},"page":"1427-1437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Effect of red\u2010light 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