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It is well known that the onset and progression of myopia are related to both genetic and environmental factors: more than 450 common genetic loci have been found to be associated with myopia, while near work and outdoor time are the main environmental risk factors. As for many complex traits, gene\u2013environment interactions are implicated in myopia development. To date, several genetic loci have been found to interact with near work or educational level. Gene\u2013environment interaction research on myopia could yield models that provide more accurate risk predictions, thus improving targeted treatments and preventive strategies. Additionally, such investigations might have the potential to reveal novel genetic information. In this review, we summarised the findings in this field and proposed some topics for future investigations.<\/jats:p>","DOI":"10.1111\/opo.13206","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T07:57:27Z","timestamp":1690185447000},"page":"1438-1448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Gene\u2013environment interaction in myopia"],"prefix":"10.1007","volume":"43","author":[{"given":"Xi","family":"He","sequence":"first","affiliation":[{"name":"Beijing Tongren Hospital Capital Medical University  Beijing China"},{"name":"Beijing Ophthalmology &amp; Visual Sciences Key Laboratory  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2828-3260","authenticated-orcid":false,"given":"Shi\u2010Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Tongren Hospital Capital Medical University  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