{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:29:57Z","timestamp":1785846597990,"version":"3.56.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To quantify the magnitude of central and peripheral scleral lens\u2010induced corneal oedema for a range of fluid reservoir thicknesses, and to compare these experimental results with theoretical models of corneal oedema both with and without limbal metabolic support (i.e., the lateral transport of metabolites and the influence of the limbal vasculature).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten young healthy participants wore scleral lenses (KATT\u2122, Capricornia Contact Lenses) fitted with low (mean 141\u2009\u03bcm), medium (482\u2009\u03bcm) and high (718\u2009\u03bcm) central fluid reservoir thickness values across three separate study visits. The scleral lens thickness, fluid reservoir thickness and stromal corneal oedema were measured using optical coherence tomography. Oedema was quantified across the central (0\u20132.5\u2009mm from the corneal apex) and peripheral (1.25\u20133\u2009mm from the scleral spur) cornea. Experimental data were compared with published theoretical models of central to peripheral corneal oedema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Stromal oedema varied with fluid reservoir thickness (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) for both central and peripheral regions. The mean (standard deviation) stromal oedema was greater for the medium (2.08 (1.21)%) and high (2.22 (1.31)%) fluid reservoir thickness conditions compared to the low condition (1.00 (1.01)%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.01). Stromal oedema gradually increased from the corneal centre to the periphery by ~0.3% on average (relative increase of 18%), but the change did not reach statistical significance. This trend of increasing, rather than decreasing, oedema towards the limbus is consistent with theoretical modelling of peripheral oedema without metabolic support from the limbus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The central and peripheral cornea displayed a similar magnitude of oedema, with increasing levels observed for medium and high fluid reservoir thicknesses. The gradual increase in oedema towards the limbus is consistent with a \u2018without limbal metabolic support\u2019 theoretical model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13221","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T05:26:00Z","timestamp":1692941160000},"page":"792-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Central and peripheral scleral lens\u2010induced corneal oedema"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-1248","authenticated-orcid":false,"given":"Asif","family":"Iqbal","sequence":"first","affiliation":[{"name":"Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Centre for Vision and Eye Research Queensland University of Technology  Brisbane Queensland 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