{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:09:19Z","timestamp":1787800159036,"version":"build-2784847793"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020485","name":"CooperVision","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020485","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmic Physiologic Optic"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Accumulated axial growth observed during a 6\u2010year clinical trial of a dual focus myopia control contact lens was used to explore different approaches to assess treatment efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Axial length measurements from 170 eyes in a 6\u2010year clinical trial of a dual focus myopia control lens (MiSight 1\u2009day, CooperVision) were analysed. Treatment groups comprised one having undergone 6\u2009years of treatment and the other (the initial control group) having 3\u2009years of treatment after 3\u2009years of wearing a single vision control lens. Efficacy was assessed by comparing accumulated ocular growth during treatment to that expected of untreated myopic and emmetropic eyes. The impact of treatment on delaying axial growth was quantified by comparing the increased time required to reach criterion growths for treated eyes and survivor analysis approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When compared to the predicted accumulated growth of untreated eyes, 6\u2009years of treatment reduced growth by 0.52\u2009mm, while 3\u2009years of treatment initiated 3\u2009years later reduced growth by 0.19\u2009mm. Accumulated differences between the growth of treated and untreated myopic eyes ranged between 67% and 52% of the untreated myopic growth, and between 112% and 86% of the predicted difference in growth between untreated myopic and age\u2010matched emmetropic eyes. Treated eyes took almost 4\u2009years longer to reach their final accumulated growth than untreated eyes. Treatment increased the time to reach criterion growths by 2.3\u20132.7 times.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Estimated growth of age\u2010matched emmetropic and untreated myopic eyes provided evidence of an accumulated slowing in axial elongation of 0.52\u2009mm over 6\u2009years, and the treated growth remained close to that expected of emmetropic eyes. Six years of dual focus myopia control delayed the time to reach the final growth level by almost 4\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/opo.13240","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T01:24:30Z","timestamp":1698456270000},"page":"199-205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Six\u2010year cumulative treatment effect and treatment efficacy of a dual focus myopia control contact lens"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9082-602X","authenticated-orcid":false,"given":"Paul","family":"Chamberlain","sequence":"first","affiliation":[{"name":"Cooper Vision Inc.  San Ramon California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-1555","authenticated-orcid":false,"given":"David Scott","family":"Hammond","sequence":"additional","affiliation":[{"name":"Cooper Vision Inc.  San Ramon California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baskar","family":"Arumugam","sequence":"additional","affiliation":[{"name":"Cooper Vision Inc.  San Ramon California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Bradley","sequence":"additional","affiliation":[{"name":"Cooper Vision Inc.  San Ramon California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-199802000-00017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001281"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10106"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.47102\/https:\/\/doi.org\/10.47102\/annals-acadmedsg.V33N1p27"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.01.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13058"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2012.06.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.01.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13059"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001410"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.9.11"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10834"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13120"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2022.10.021"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001873"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12621"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0945"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2023.02.002"},{"key":"e_1_2_9_20_1","article-title":"Influence of age and race on axial elongation in myopic children","volume":"63","author":"Shamp W","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12812"},{"key":"e_1_2_9_22_1","first-page":"1110","article-title":"Myopia control effect of defocus incorporated multiple segments (DIMS) spectacle lens in Chinese children: results of a 3\u2010year follow\u2010up study","volume":"106","author":"Lam CS","year":"2022","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-021-01571-6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-021-01452-y"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12305"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12403"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15038"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003653"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13120"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201032700\u20107"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100923"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001970"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.11.42"}],"container-title":["Ophthalmic and Physiological Optics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/opo.13240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:24:05Z","timestamp":1767785045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/opo.13240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,27]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/opo.13240"],"URL":"https:\/\/doi.org\/10.1111\/opo.13240","archive":["Portico"],"relation":{},"ISSN":["0275-5408","1475-1313"],"issn-type":[{"value":"0275-5408","type":"print"},{"value":"1475-1313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,27]]},"assertion":[{"value":"2023-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}